KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
NADPH | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
membrane | isoforms 4 and 10 | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | Homo sapiens | - |
estrone + NADH | - |
? | |
estrone + NADPH + H+ | Homo sapiens | final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain | estradiol-17beta + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms 4, 5, 7, 8, 10, and 11, 17beta-HSD 4, 5, 7, 8, 10, and 11 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ | isoforms differs in substrate specificity and tissue distribution, some enzyme forms displays also other activities such as type 4 that acts also as a short chain alcohol dehydrogenase and hydratase and type 10, that is identical to endoplasmic amyloid-beta-binding protein and mitochondrial short chain L-3-hydroxyacyl-CoA dehydrogenase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
cardiac muscle | low level | Homo sapiens | - |
liver | high activity | Homo sapiens | - |
placenta | isoform 8 is highly expressed, low level of isoform 5 | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
temporal lobe | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + NADPH | - |
Homo sapiens | androst-4-ene-17beta-ol-3-one + NADP+ | - |
? | |
estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
? | |
estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
? | |
estrone + NADPH + H+ | final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain | Homo sapiens | estradiol-17beta + NADP+ | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | estrone reduction | Homo sapiens |
9 | - |
estradiol-17beta oxidation | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9.5 | estrone reduction | Homo sapiens |
7.5 | 9.5 | estradiol-17beta oxidation | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | oxidation | Homo sapiens | |
NADPH | reduction | Homo sapiens |