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Information on EC 2.4.1.92 - (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.92
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EC Tree
IUBMB Comments
This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
gm3 synthase, gm2 synthase, gm2/gd2 synthase, gd2 synthase, gd2/gm2 synthase, beta1,4-n-acetylgalactosaminyltransferase, beta4galnacta, n-acetylgalactosaminyltransferase i, galgt1, st3gal v, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide
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PATHWAY SOURCE
PATHWAYS
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