Reference on EC 3.2.1.52 - beta-N-acetylhexosaminidase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kinoshita, K.; Taniguchi, N.; Makita, A.; Narita, M.; Oikawa, K.
Purification and characterization of beta-N-acetylhexosaminidase I from human placenta
J. Biochem.
104
827-831
1988
Homo sapiens
Dewji, N.N.; De-Keyser, D.R.; Stirling, J.L.
Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver
Biochem. J.
234
157-162
1986
Homo sapiens
Kress, B.C.; Hirani, S.; Freeze, H.H.; Little, L.; Miller, A.L.
Mucolipidosis III beta-N-acetyl-D-hexosaminidase A. Purification and properties
Biochem. J.
207
421-428
1982
Homo sapiens
Potier, M.; Teitelbaum, J.; Melancon, S.B.; Dallaire, L.
Purification and some properties of liver and brain beta-N-acetyl-hexosaminidase S
Biochim. Biophys. Acta
566
80-87
1979
Homo sapiens
Dawson, G.; Propper, R.L.; Dorfman, A.
Partial purification of beta-N-acetylhexosaminidase A by affinity chromatography
Biochem. Biophys. Res. Commun.
54
1102-1110
1973
Homo sapiens
Perez, L.F.; Ribeiro, H.M.; Casal, J.A.; Pinto, R.A.; Sa Miranda, M.C.; Tutor, J.C.
Thermodynamic characterization of the mutated isoenzyme A of beta-N-acetylhexosaminidase in GM2-gangliosidosis B1 variant
Clin. Chim. Acta
285
45-51
1999
Homo sapiens
Ribeiro, M.G.; Pinto, R.A.; Dos Santos, M.R.; Maia, M.; Sa Miranda, M.C.
Biochemical characterization of beta-acetylhexosaminidase in different biological specimens from eleven patients with GM2-gangliosidosis B1 variant
J. Inherit. Metab. Dis.
14
715-720
1991
Homo sapiens
Prence, E.M.; Zalewski, I.; Natowicz, M.R.
Unusual thermolability properties of beta-hexosaminidase: Studies of enzyme from cultured cells and clinical implications
Am. J. Med. Genet.
65
320-324
1996
Homo sapiens
Perez, L.F.; Martinez, M.I.; Ribeiro, H.M.; Pinto, R.A.; Sa Miranda, M.C.; Tutor, J.C.
Characterization of the isoenzyme profile of beta-N-acetylhexosaminidase in the urine of newborns
Clin. Chem. Lab. Med.
37
765-769
1999
Homo sapiens
Church, W.B.; Swenson, L.; James, M.N.G.
Crystallization of human beta-N-acetylhexosaminidase B
J. Mol. Biol.
227
577-580
1992
Homo sapiens
Miller, A.L.; Norton, V.; Robertson, R.; Jenks, M.; Yeh, R.Y.; Wright, D.
Light and heavy lysosomes: characterization of N-acetyl-beta-D-hexosaminidase isolatad from normal and I-cell disease lymphoblasts
Glycobiology
3
313-318
1993
Homo sapiens
Den Tandt, W.R.; Scharpe, S.
Characteristics of hexosaminidase A in homogenates of white blood cells using methylumbelliferyl-N-acetyl-beta-D-glucosaminide-6-sulphate as substrate
Clin. Chim. Acta
199
231-236
1991
Homo sapiens
Prence, E.M.; Natowicz, M.R.; Zalewski, I.
Unusual thermolability properties of leukocyte beta-hexosaminidase: Implications in screening for carriers of Tay-Sachs disease
Clin. Chem.
39
1811-1814
1993
Homo sapiens
Mahuran, D.J.
Characterization of human placental beta-hexosaminidase I2: Proteolytic processing intermediates of hexosaminidase A
J. Biol. Chem.
265
6794-6799
1990
Homo sapiens
Verpoorte, J.A.
Isolation and characterization of the major beta-N-acetyl-D-glucosaminidase from human plasma
Biochemistry
13
793-799
1974
Homo sapiens
Stirling, J.L.
Separation and characterization of N-acetyl-beta-glucosaminidases A and P from maternal serum
Biochim. Biophys. Acta
271
154-162
1972
Homo sapiens
Sharma, R.; Bukovac, S.; Callahan, J.; Mahuran, D.
A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside
Biochim. Biophys. Acta
1637
113-118
2003
Homo sapiens
Mark, B.L.; Mahuran, D.J.; Cherney, M.M.; Zhao, D.; Knapp, S.; James, M.N.
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease
J. Mol. Biol.
327
1093-1109
2003
Homo sapiens (P07686), Homo sapiens
Maier, T.; Strater, N.; Schuette, C.G.; Klingenstein, R.; Sandhoff, K.; Saenger, W.
The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease
J. Mol. Biol.
328
669-681
2003
Homo sapiens
Lemieux, M.J.; Mark, B.L.; Cherney, M.M.; Withers, S.G.; Mahuran, D.J.; James, M.N.
Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis
J. Mol. Biol.
359
913-929
2006
Homo sapiens
Olszewska, E.; Olszewski, S.; Borzym-Kluczyk, M.; Zwierz, K.
Role of N-acetyl-beta-d-hexosaminidase in cholesteatoma tissue
Acta Biochim. Pol.
54
365-370
2007
Homo sapiens
Akeboshi, H.; Chiba, Y.; Kasahara, Y.; Takashiba, M.; Takaoka, Y.; Ohsawa, M.; Tajima, Y.; Kawashima, I.; Tsuji, D.; Itoh, K.; Sakuraba, H.; Jigami, Y.
Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta
Appl. Environ. Microbiol.
73
4805-4812
2007
Homo sapiens (P07686), Homo sapiens
Tropak, M.B.; Blanchard, J.E.; Withers, S.G.; Brown, E.D.; Mahuran, D.
High-throughput screening for human lysosomal beta-N-acetyl hexosaminidase inhibitors acting as pharmacological chaperones
Chem. Biol.
14
153-164
2007
Homo sapiens
Borzym-Kluczyk, M.; Radziejewska, I.; Olszewska, E.; Szajda, S.; Zwierz, K.
Statistical evaluation of the isoform patterns of N-acetyl-beta-hexosaminidase from human renal cancer tissue separated by isoelectrofocusing
Clin. Biochem.
40
403-406
2007
Homo sapiens
Massaccesi, L.; Lombardo, A.; Venerando, B.; Tettamanti, G.; Goi, G.
Isoenzyme pattern and partial characterization of hexosaminidases in the membrane and cytosol of human erythrocytes
Clin. Biochem.
40
467-477
2007
Homo sapiens
Tassi, C.; Angelini, A.; Beccari, T.; Capodicasa, E.
Fluorimetric determination of activity and isoenzyme composition of N-acetyl-beta-D-hexosaminidase in seminal plasma of fertile men and infertile patients with secretory azoospermia
Clin. Chem. Lab. Med.
44
843-847
2006
Homo sapiens
Marciniak, J.; Zalewska, A.; Popko, J.; Zwierz, K.
Optimization of an enzymatic method for the determination of lysosomal N-acetyl-beta-D-hexosaminidase and beta-glucuronidase in synovial fluid
Clin. Chem. Lab. Med.
44
933-937
2006
Homo sapiens
Borzym-Kluczyk, M.; Olszewska, E.; Radziejewska, I.; Lewszuk, A.; Zwierz, K.
Isoenzymes of N-acetyl-beta-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study
Clin. Chem. Lab. Med.
46
131-136
2008
Homo sapiens
Popko, J.; Marciniak, J.; Zalewska, A.; Gorska, A.; Zwierz, K.; Sierakowski, S.; Urban, M.
Activity of N-acetyl-beta-hexosaminidase and its isoenzymes in serum and synovial fluid from patients with different arthropathies
Clin. Exp. Rheumatol.
24
690-693
2007
Homo sapiens
Tropak, M.B.; Mahuran, D.
Lending a helping hand, screening chemical libraries for compounds that enhance beta-hexosaminidase A activity in GM2 gangliosidosis cells
FEBS J.
274
4951-4961
2007
Homo sapiens
Tomasiak, M.M.; Tomasiak, M.; Zietkowski, Z.; Skiepko, R.; Bodzenta-Lukaszyk, A.
N-Acetyl-beta-hexosaminidase activity in asthma
Int. Arch. Allergy Immunol.
146
133-137
2008
Homo sapiens
Scaffidi, A.; Stubbs, K.A.; Dennis, R.J.; Taylor, E.J.; Davies, G.J.; Vocadlo, D.J.; Stick, R.V.
A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases
Org. Biomol. Chem.
5
3013-3019
2007
Bacteroides thetaiotaomicron, Homo sapiens
Dudzik, D.; Knas, M.; Gocal, M.; Borzym-Kluczyk, M.; Szajda, S.D.; Knas-Karaszewska, K.; Tomaszewski, J.; Zwierz, K.
Activity of N-acetyl-beta-D-hexosaminidase (HEX) and its isoenzymes A and B in human milk during the first 3 months of breastfeeding
Adv. Med. Sci.
53
300-304
2008
Homo sapiens
Gutternigg, M.; Rendic, D.; Voglauer, R.; Iskratsch, T.; Wilson, I.B.
Mammalian cells contain a second nucleocytoplasmic hexosaminidase
Biochem. J.
419
83-90
2009
Homo sapiens, Mus musculus (Q3U4H6), Mus musculus
Rountree, J.S.; Butters, T.D.; Wormald, M.R.; Boomkamp, S.D.; Dwek, R.A.; Asano, N.; Ikeda, K.; Evinson, E.L.; Nash, R.J.; Fleet, G.W.
Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease
ChemMedChem
4
378-392
2009
Bos taurus, Homo sapiens, Canavalia sp.
Olszewska, E.; Borzym-Kluczyk, M.; Rzewnicki, I.; Rutkowska, J.; Knas, M.; Rogowski, M.; Waniewska, E.; Wielgosz, R.
Hexosaminidase as a new potential marker for larynx cancer
Clin. Biochem.
42
1187-1189
2009
Homo sapiens
Szajda, S.D.; Snarska, J.; Jankowska, A.; Puchalski, Z.; Zwierz, K.
Isoenzymes A and B of N-acetyl-beta-D-hexosaminidase in serum and urine of patients with pancreatic cancer
Hepatogastroenterology
55
695-698
2008
Homo sapiens
Macauley, M.S.; Whitworth, G.E.; Debowski, A.W.; Chin, D.; Vocadlo, D.J.
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors
J. Biol. Chem.
280
25313-25322
2005
Homo sapiens
Stubbs, K.A.; Zhang, N.; Vocadlo, D.J.
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase
Org. Biomol. Chem.
4
839-845
2006
Homo sapiens
Ho, C.W.; Popat, S.D.; Liu, T.W.; Tsai, K.C.; Ho, M.J.; Chen, W.H.; Yang, A.S.; Lin, C.H.
Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors
Chem. Biol.
5
489-497
2010
Homo sapiens
Alteen, M.G.; Oehler, V.; Nemcovicova, I.; Wilson, I.B.; Vocadlo, D.J.; Gloster, T.M.
Mechanism of human nucleocytoplasmic hexosaminidase D
Biochemistry
55
2735-2747
2016
Homo sapiens
Dong, L.; Shen, S.; Chen, W.; Lu, H.; Xu, D.; Jin, S.; Yang, Q.; Zhang, J.
Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors Design, synthesis, molecular docking and MD simulations
Bioorg. Med. Chem.
27
2315-2322
2019
Homo sapiens, Ostrinia furnacalis (Q06GJ0)
Shen, S.; Chen, W.; Dong, L.; Yang, Q.; Lu, H.; Zhang, J.
Design and synthesis of naphthalimide group-bearing thioglycosides as novel beta-N-acetylhexosaminidases inhibitors
J. Enzyme Inhib. Med. Chem.
33
445-452
2018
Homo sapiens
Tropak, M.B.; Zhang, J.; Yonekawa, S.; Rigat, B.A.; Aulakh, V.S.; Smith, M.R.; Hwang, H.J.; Ciufolini, M.A.; Mahuran, D.J.
Pyrimethamine derivatives insight into binding mechanism and improved enhancement of mutant beta-N-acetylhexosaminidase activity
J. Med. Chem.
58
4483-4493
2015
Homo sapiens
