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Literature summary for 3.2.1.52 extracted from

  • Mahuran, D.J.
    Characterization of human placental beta-hexosaminidase I2: Proteolytic processing intermediates of hexosaminidase A (1990), J. Biol. Chem., 265, 6794-6799.
    View publication on PubMed
Search for more literature for 3.2.1.52

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 major Hex I2 form: alpha, beta, 1 * 66000 + 1 * 66000, beta chain 2 residues short of being identical to alpha chain, SDS-PAGE Homo sapiens
130000
-
 Hex I2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-beta-D-hexosaminides + H2O Homo sapiens
-
 N-acetyl-D-hexosamines
-
 ?

Organic Solvent Stability

Organic Solvent Comment Organism
dithiothreitol reduction, produces fragments of 63000, 56000, 36000 and 28000 Da Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-beta-D-hexosaminides + H2O
-
 Homo sapiens N-acetyl-D-hexosamines
-
 ?

Subunits

Subunits Comment Organism
dimer Hex A: alpha beta, Hex B: beta beta Homo sapiens
dimer major Hex I2 form: alpha, beta, 1 * 66000 + 1 * 66000, beta chain 2 residues short of being identical to alpha chain, SDS-PAGE Homo sapiens
More
-
 Homo sapiens