EC Number   |
Protein Variants |
Reference |
|---|
   3.4.23.46 | D257A |
the mutation causes essentially complete loss of gamma-secretase activity |
712447 |
| 3.4.23.46 | L435F |
the mutation resides in a conserved C-terminal PAL sequence implicated in active site conformation and catalytic activity, the mutation causes a nearly complete loss of gamma-secretase activity |
712447 |
| 3.4.23.46 | L435R |
the mutation causes essentially complete loss of gamma-secretase activity |
712447 |
| 3.4.23.46 | more |
6 x His-tagged proBACE1 for cristallization |
638919 |
| 3.4.23.46 | more |
BACE1 knockout mice instrumental in validating BACE1 as regulator of voltage-gated sodium channels and neuronal activity |
683908 |
| 3.4.23.46 | more |
BACE1 knockout mice, evidence that neither beta-secretase nor Abeta plays a vital role in mouse physiology |
638913 |
| 3.4.23.46 | more |
BACE1-driven reporter protein expression, transfection of rat cortical cultures |
683790 |
| 3.4.23.46 | more |
BACE1-null mice instrumental in validating roles of BACE1 in regulation of myelination |
683911 |
| 3.4.23.46 | more |
common BACE1 polymorphisms and putatively functional variants have no significant influence on genetic susceptibility to Alzheimer's disease, or platelet beta-secretase activity, in the Caucasian Northern Irish population |
700445 |
| 3.4.23.46 | more |
genotyping of 11 single nucleotide polymorphisms covering the complete BACE1 gene reveals no single-marker or haplotypic association with Alzheimer's disease. Neither ADAM10 coding for alpha-secretase nor BACE1 present with any evidence to suggest that they are major candidate genes involved in conferring risk for Alzheimer's disease |
700414 |
