Cloned (Comment) | Organism |
---|---|
PS1 is expressed in mouse embryo fibroblasts lacking endogenous PS1 and PS2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D257A | the mutation causes essentially complete loss of gamma-secretase activity | Homo sapiens |
L435F | the mutation resides in a conserved C-terminal PAL sequence implicated in active site conformation and catalytic activity, the mutation causes a nearly complete loss of gamma-secretase activity | Homo sapiens |
L435R | the mutation causes essentially complete loss of gamma-secretase activity | Homo sapiens |
P433L | the mutation causes essentially complete loss of gamma-secretase activity | Homo sapiens |
P436Q | the mutation causes partial loss of enzyme function | Homo sapiens |
P436S | the mutation causes partial loss of enzyme function | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
beta-amyloid peptide 40 + beta-amyloid peptide 42 | - |
? | |
N-cadherin + H2O | Homo sapiens | - |
? | - |
? | |
Notch protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | beta-amyloid peptide 40 + beta-amyloid peptide 42 | - |
? | |
N-cadherin + H2O | - |
Homo sapiens | ? | - |
? | |
Notch protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-secretase | - |
Homo sapiens |
presenilin-1 | catalytic component of the multisubunit gamma-secretase complex | Homo sapiens |
presenilin-2 | catalytic component of the multisubunit gamma-secretase complex | Homo sapiens |