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Literature summary for 3.4.23.46 extracted from

  • Kim, D.Y.; Carey, B.W.; Wang, H.; Ingano, L.A.; Binshtok, A.M.; Wertz, M.H.; Pettingell, W.H.; He, P.; Lee, V.M.; Woolf, C.J.; Kovacs, D.M.
    BACE1 regulates voltage-gated sodium channels and neuronal activity (2007), Nat. Cell Biol., 9, 755-764.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.46

Protein Variants

Protein Variants Comment Organism
additional information BACE1 knockout mice instrumental in validating BACE1 as regulator of voltage-gated sodium channels and neuronal activity Homo sapiens
additional information BACE1 knockout mice instrumental in validating BACE1 as regulator of voltage-gated sodium channels and neuronal activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information membrane excitability normalized by BACE1 inhibitor GL189 in Alzheimer disease patients reveals association between BACE1 and regulatory role on voltage-gated sodium channel by cleavage of beta2 subunit Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta2 subunit of voltage-gated sodium channel + H2O Homo sapiens
-
 ?
-
 ?
beta2 subunit of voltage-gated sodium channel + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-
Mus musculus P56818
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain Alzheimer disease patients, endogenous processing of beta2 subunit of voltage-gated sodium channel found to be increased Homo sapiens
-
brain cleavage products of BACE1 determined, sodium-current densities reduced in neuroblastoma cells and hippocampal cells of transgenic mice Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 beta2 subunit of voltage-gated sodium channel analyzed as substrate of BACE1, increase of mRNA and protein levels of pore-forming alpha subunit of sodium channel after cleavage observed, regulation of alpha subunit of voltage-gated sodium channel mediated through BACE1, association between BACE1 and cell-surface sodium current densities shown Homo sapiens
additional information
-
 beta2 subunit of voltage-gated sodium channel analyzed as substrate of BACE1, increase of mRNA and protein levels of pore-forming alpha subunit of sodium channel after cleavage observed, regulation of alpha subunit of voltage-gated sodium channel mediated through BACE1, association between BACE1 and cell-surface sodium current densities shown Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta2 subunit of voltage-gated sodium channel + H2O
-
 Homo sapiens ?
-
 ?
beta2 subunit of voltage-gated sodium channel + H2O
-
 Mus musculus ?
-
 ?
beta2 subunit of voltage-gated sodium channel + H2O substrate cleavage investigated, cleavage products beta2-CTFbeta and beta2-ICD characterized, multiple roles in regulating neuronal function through regulating of neuronal BACE1 substrate proteins discussed Homo sapiens ?
-
 ?
beta2 subunit of voltage-gated sodium channel + H2O substrate cleavage investigated, cleavage products beta2-CTFbeta and beta2-ICD characterized, multiple roles in regulating neuronal function through regulating of neuronal BACE1 substrate proteins discussed Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
BACE1
-
 Mus musculus
beta-secretase
-
 Homo sapiens
beta-secretase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
 cleavage of beta2 subunit of voltage-gated sodium channel by BACE1 observed at pH 4.5 but not at pH 7 Homo sapiens
4.5
-
 cleavage of beta2 subunit of voltage-gated sodium channel by BACE1 observed at pH 4.5 but not at pH 7 Mus musculus