EC Number   |
General Information |
Reference |
|---|
    6.3.1.2 | drug target |
since glutamine synthetase is the first metabolic enzyme involved in Trypanosoma cruzi evasion from the parasitophorous vacuole it is a potential target for designing anti-Trypanosoma cruzi drugs |
-, 743570 |
| 6.3.1.2 | evolution |
glutamine synthetase (GS), a key enzyme in plant nitrogen metabolism, is encoded by a small family of highly homologous nuclear genes that produce cytosolic (GS1) and plastidic (GS2) isoforms. Compared to GS1, GS2 proteins have two extension peptides, one at the N- and the other at the C-terminus, which show a high degree of conservation among plant species |
746127 |
| 6.3.1.2 | evolution |
two GS isoforms are encoded in the genome of higher plants: the cytosolic Gln synthetase isoform (GS1) and the chloroplastic Gln synthetase isoform (GS2). GS2 is encoded by a single gene (Gln-2), whereas GS1 is encoded by a multigene family, suggesting a complex role of GS1 with respect to plant N assimilation |
746115 |
| 6.3.1.2 | evolution |
Unigene0016999 and Unigene0017002 belong to isozyme GSI, while Unigene0015608, Unigene0022741, and Unigene0002184 belong to isozyme GSII, and Unigene0002194 belongs to isozyme GSIII, sequence comparisons and phylogenetic tree, overview |
744149 |
| 6.3.1.2 | malfunction |
a gln1-1:gln1-2 double mutant shows impairment of seed germination and seedling establishment, phenotype, overview |
745466 |
| 6.3.1.2 | malfunction |
astrocytes enable the proliferation of GS-negative LN18 iRFP4 cells without Gln supplementation |
745832 |
| 6.3.1.2 | malfunction |
depletion of the enzyme in Hep-3B cells by transduction with two independent shRNAs reduces LC3-II formation. Conversely, exogenous enzyme overexpression increases autophagic activity in SK-Hep1 cells. Glutamine synthetase (GS) overexpression significantly increases sorafenib sensitivity in hepatocellular carcinoma cells |
744850 |
| 6.3.1.2 | malfunction |
enzyme mutants, single mutant gln1-2 and gln1-1:gln1-2 double mutant, show impairment of seed germination and seedling establishment. The negative effect of Gln1-2 deficiency, causing slower seedling development in the mutants, is associated with reduced N remobilization from the cotyledons and can be fully alleviated by exogenous N supply. Phenotypes, overview |
745466 |
| 6.3.1.2 | malfunction |
OsGS1;2 homozygously inserted mutants show severe reduction in active tiller number and hence panicle number at harvest. The mutants show marked reductions in contents of glutamine, glutamate, asparagine and aspartate, but an increase in free ammonium ions compared to the wild-type |
728465 |
| 6.3.1.2 | malfunction |
the total capacity of the enzyme-mediated ligation of free ammonium and glutamate to form glutamine in the leaves of maize plants is not impaired upon severe magnesium starvation. The total GS-mediated primary or secondary assimilation of free NH4+ is not a limiting enzymatic reaction under Mg-deficiency and thus cannot be accountable for the observed restriction of plant growth and productivity in Mg-deficient maize, phenotype, overview |
746155 |
