EC Number   |
General Information |
Reference |
|---|
   5.6.2.2 | malfunction |
downregulation of Topo II by RNAi or mutations in the Top2 gene result in disruption of Su(Hw) insulator function, mediated by the Mod(mdg4)2.2 protein, which is a unique component of the Su(Hw) insulator complex. Mutations in Top2 cause a slight decrease of Mod(mdg4)2.2 transcript but have a dramatic effect on Mod(mdg4)2.2 protein levels. Mod(mdg4)2.2 is not present at insulator sites in Top2 mutants, while Su(Hw) is present |
716695 |
| 5.6.2.2 | malfunction |
GC axon and tectal neurite targeting are aberrant in the noto mutant tectum. The noto mutant also has neurite organization defects in the tectal neuropil, phenotype, overview. In chimeras in which wild-type axons innervate a mutant tectum, laminar targeting is free of errors. By contrast, mutant axons innervating the SFGS lamina of wild-type tectum appear disorganized and trespass between sublaminae |
-, 714804 |
| 5.6.2.2 | malfunction |
in bloodstream form Trypanosoma brucei, RNAi-mediated depletion of topoisomerase-IIalpha, but not topoisomerase-IIbeta, results in the abolition of centromere-localized activity and is lethal |
-, 716381 |
| 5.6.2.2 | malfunction |
the migration of postmitotic cortical neurons is affected in Top IIbeta mutant embryos |
716348 |
| 5.6.2.2 | malfunction |
topoisomerase II poisons generate DNA damage, in addition to inhibition of enzyme activity, and cause delay of cell cycle progression due to DNA damage checkpoints |
705865 |
| 5.6.2.2 | metabolism |
mechanistically link of DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription |
716925 |
| 5.6.2.2 | more |
cortical neurons in Top IIbeta knockout mice show downregulated expression levels of certain neuronal genes, i.e. Robo1, catenin alpha 2, cadherin 8, and synaptotagmin |
716348 |
| 5.6.2.2 | more |
histone deacetylase inhibition, e.g., by trichostatin A, redistributes topoisomerase IIbeta from heterochromatin to euchromatin, overview. Treatment with trichostatin A displaces topoIIbeta from the heterochromatin with similar kinetics to the displacement of HP1beta proteins |
716400 |
| 5.6.2.2 | more |
ionising radiation does not influence enzyme-DNA complexes and does not produce topoisomerase II-DNA adducts, overview. Topoisomerase II-DNA complexes inwild-type cells but not in TOP2beta-/- cells increase significantly at 24 hours with the proteasome inhibitor MG132, suggesting topoisomerase IIbeta adducts are removed by the proteasome |
715994 |
| 5.6.2.2 | more |
passage of the full length and truncated enzymes in the presence of a number of supporting metal ions shows no difference in relative decatenation between isoforms |
716692 |
