Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Ju, B.
    A topoisomerase beta-mediated dsDNA break required for regulated transcription (2011), Science, 332, 1798-1802.
No PubMed abstract available
Search for more literature for 5.6.2.2

Protein Variants

Protein Variants Comment Organism
additional information transient transfection of MCF-7 cells using enzymatically inactive mutant mouse TopoIIbeta (Pro723-Leu723) with human-specific TopoIIbeta small interfering RNA results in no transcription activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase II
-
 Homo sapiens
DNA topoisomerase IIbeta
-
 Homo sapiens
topoIIbeta
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism mechanistically link of DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription Homo sapiens
physiological function DNA topoisomerase II is required for transcriptional initiation, it associates with gene promoter regions and can generate breaks in double-stranded DNA. Signal-dependent activation of gene transcription by nuclear receptors and other classes of DNA binding transcription factors, including activating protein 1, requires DNA topoisomerase IIbeta-dependent, transient, site-specific dsDNA break formation Homo sapiens