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Information on EC 5.6.2.2 - DNA topoisomerase (ATP-hydrolysing)

for references in articles please use BRENDA:EC5.6.2.2

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IUBMB Comments

The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.6.2.1 DNA topoisomerase).

The enzyme appears in viruses and cellular organisms
Reaction Schemes
ATP-dependent breakage, passage and rejoining of double-stranded DNA

Synonyms
atpase, topoisomerase ii, dna gyrase, topo ii, gyrase, top2a, dna topoisomerase ii, topoisomerase iialpha, topo iialpha, topoisomerase ii alpha, more