EC Number   |
General Information |
Reference |
|---|
   5.4.99.8 | evolution |
cycloartenol synthase belongs to the 2-3 oxidosqualene cyclases (OCSs) gene family |
749078 |
| 5.4.99.8 | evolution |
determination of evolutionary relationship of squalene synthases (SQSs) or cycloartneol synthases (CASs) from different plants, phylogenetic trees are constructed, overview |
746683 |
| 5.4.99.8 | evolution |
the enzyme belongs to the family of 2,3-oxidosqualene cyclases (OSCs). A key step in the synthesis of cholesterol in red algae may be the reduction of the C-24(25) double bond by a DHCR24-like enzyme |
749096 |
| 5.4.99.8 | evolution |
the enzyme belongs to the fammily of 2,3-oxidosqualene cyclases, OSCs |
749137 |
| 5.4.99.8 | evolution |
the enzyme belongs to the oxidosqualene cyclase OSC superfamily of enzymes |
-, 727980 |
| 5.4.99.8 | evolution |
the enzyme belongs to the oxidosqualene cyclases (OSCs), enzymes that play a key role in control of the biosynthesis of phytosterols and triterpene saponins |
747979 |
| 5.4.99.8 | malfunction |
antisense inhibition of cycloartenol synthase results in decreased phytosterol levels and enhanced ginsenoside levels |
706246 |
| 5.4.99.8 | malfunction |
in vivo application of inhibitor RO 48-8071 TBY-2 cells in short-term treatments (24 h) results in accumulation of oxidosqualene with no changes in the final sterol products. Long-term treatments (6 days) induces downregulation in gene expression not only of CAS but also of the SMT2 gene coding sterol methyltransferase 2 (EC 2.1.1.41) explaining some of the increase in 24-methyl sterols at the expense of the 24-ethyl sterols stigmasterol and sitosterol |
748519 |
| 5.4.99.8 | malfunction |
inhibition of CAS expression, e.g. by RNAi, can decrease the synthesis metabolic flux of the phytosterol branch |
748718 |
| 5.4.99.8 | metabolism |
building blocks for plant sterol biosynthesis, involving enzyme CAS, are provided by the mevalonate (MVA) pathway, overview |
748519 |
