EC Number   |
General Information |
Reference |
|---|
    2.4.1.133 | malfunction |
an antibody against beta-1,4-GalT-I attenuates both lipopolysaccharide-induced microglial activation and phagocytosis |
705941 |
| 2.4.1.133 | metabolism |
beta-1,4-galactosyltransferase 7 (beta4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan chains |
759068 |
| 2.4.1.133 | physiological function |
beta-1,4-galactosyltransferase I is a key inflammatory mediator that plays a critical role in the initiation and maintenance of inflammatory reaction in diseases, beta-1,4-GalT-I is associated with E-selectin during the pathological process of secondary response after Spinal cord injury |
704802 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT I might play important roles in Schwann cells during the regeneration and degeneration of the injured sciatic nerve, enzyme plays in important role in Schwann cells in vivo and vitro during pathology, beta-1,4-GalT can catalyze the galactose from UDP-galactose to the terminal N-acetylglucosamine residues on elongating oligosaccharide chains, which are suggested to be involved in various cellular functions including cell-cell and cell-matrix interactions during embryogenesis |
704790 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT-I may play an important role in adhesion and migration of Schwann cells during inflammation, enzyme is a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases, the long beta-1,4-GalT-I isoform, due to the extra 13 amino acids at the amino-termini, is implicated in targeting the protein to cell surface, and acts as a recognition molecule associated with a variety of biological functions, including sperm-egg interactions, morula compaction, embryonic maturation, embryonal carcinoma cell spreading, neurite extension, and mesenchymal cell migration |
704010 |
| 2.4.1.133 | physiological function |
beta-1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site and mediating microgliosis |
705941 |
| 2.4.1.133 | physiological function |
beta1,4-Galactosyltransferase I is a key enzyme in glycobiology mediating several biological mechanisms. The enzyme possibly regulate mutual uterus-embryo adhesion and embryo implantation by regulating cell surface Lewis-Y glycan expression |
736177 |
| 2.4.1.133 | physiological function |
beta1,4-GalT I might play important roles in the regeneration of the injuried sciatic nerve |
705215 |
| 2.4.1.133 | physiological function |
beta1,4-GalT V might plays important roles in the regeneration of the injuried sciatic nerve |
705215 |
| 2.4.1.133 | physiological function |
enzyme is involved in the biosynthesis of the tetrasaccharide linker protein region (glucuronic acid beta1,3galactose beta1,3galactose beta1,4xylose beta1) of proteoglycans, by catalysing the transfer of galactose from the uridine 5-diphosphogalactose to a xylose residue, this reaction is rate-limiting in glycosaminoglycan biosynthesis |
702125 |
