Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-diamino-2,3-dicyano-1,4-bis-(2-aminophenylthio)butadiene | 0-10 microM of specific inhibitor U0126 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide | Rattus norvegicus | |
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol | 10-30 microM of specific inhibitor SB202190 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide | Rattus norvegicus | |
pyrazolanthrone | 10-50 microM of specific inhibitor SP600125 of MAP kinase cascade inhibits beta-1,4-GalT I mRNA production induced by lipopolysaccharide | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + O-beta-D-xylosylprotein | Rattus norvegicus | - |
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RSC96 cell | - |
Rattus norvegicus | - |
Schwann cell | - |
Rattus norvegicus | - |
sciatic nerve | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + O-beta-D-xylosylprotein | - |
Rattus norvegicus | UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase I | - |
Rattus norvegicus |
beta-1,4-GalT | - |
Rattus norvegicus |
beta-1,4-GalT I | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the beta-1,4-GalT I mRNA reaches peaks at 2 weeks after sciatic nerve crush and 3 days after sciatic nerve transection in a dose-dependent manner, in inflammation, lipopolysaccharide administration affects beta-1,4-GalT I mRNA expression in sciatic nerve in a time- and dose-dependent manner, and beta-1,4-GalT I mRNA is expressed mainly in Schwann cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | beta-1,4-GalT I might play important roles in Schwann cells during the regeneration and degeneration of the injured sciatic nerve, enzyme plays in important role in Schwann cells in vivo and vitro during pathology, beta-1,4-GalT can catalyze the galactose from UDP-galactose to the terminal N-acetylglucosamine residues on elongating oligosaccharide chains, which are suggested to be involved in various cellular functions including cell-cell and cell-matrix interactions during embryogenesis | Rattus norvegicus |