Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.133 extracted from

  • Chen, J.; Wang, H.; Yang, H.; Huang, X.; Zhu, J.; Hu, L.; Qian, J.; Yang, J.; Zhou, D.; Ni, X.; Shen, A.; Cheng, C.
    beta-1,4-Galactosyltransferase-I participates in lipopolysaccharide induced reactive microgliosis (2009), Neurotoxicology, 30, 1107-1113.
    View publication on PubMed
Search for more literature for 2.4.1.133

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
microglia
-
 Rattus norvegicus
-
primary cell line mixed neuron-glial cultures prepared from the brains of embryonic days 16-17 rats Rattus norvegicus
-
ventral midbrain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase-I
-
 Rattus norvegicus
beta-1,4-GalT-I
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus beta-1,4-GalT-I is strongly induced in the ventral midbrain by intranigral injection of lipopolysaccharide, significant increase in beta-1,4-GalT-I mRNA at 8 h after focal injection of lipopolysaccharide, and lastes to 18 h, then decreases gradually up

General Information

General Information Comment Organism
malfunction an antibody against beta-1,4-GalT-I attenuates both lipopolysaccharide-induced microglial activation and phagocytosis Rattus norvegicus
physiological function beta-1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site and mediating microgliosis Rattus norvegicus