EC Number   |
General Information |
Reference |
|---|
    1.14.14.17 | malfunction |
enzyme downregulation inhibits the tumorigenicity of hepatocellular carcinoma cells in vitro and in vivo |
735329 |
| 1.14.14.17 | malfunction |
squalene epoxidase inhibition may be responsible for dermatitis and neuropathy |
735203 |
| 1.14.14.17 | metabolism |
enzyme undergoes cholesterol-dependent proteasomal degradation when cholesterol is in excess. The amphipathic helix within the first 100 amino acids of squalene monooxygenase attaches reversibly to the ER membrane depending on cholesterol levels. With excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal |
745376 |
| 1.14.14.17 | metabolism |
part of cholesterol synthesis pathway |
697143 |
| 1.14.14.17 | metabolism |
squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner |
700657 |
| 1.14.14.17 | metabolism |
squalene epoxidase catalyzes the first oxygenation step in phytosterol and triterpenoid saponin biosynthesis and is suggested to represent one of the rate-limiting enzymes in this pathway. Expression of PgSQE1 and PgSQE2 are regulated in a different manner, and that PgSQE1 regulates ginsenoside biosynthesis, but not that of phytosterols in Panax ginseng |
700657 |
| 1.14.14.17 | metabolism |
squalene epoxidase is a key FAD-dependent enzyme of ergosterol and cholesterol biosynthetic pathways |
715725 |
| 1.14.14.17 | metabolism |
the enzyme catalyzes a key steps in the biosynthesis of cyclic terpenoids |
759950 |
| 1.14.14.17 | metabolism |
the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis |
735203 |
| 1.14.14.17 | metabolism |
the isoform SQE3 is able to complement isoform SQE1 function |
734739 |
