Any feedback?
Literature summary for 1.14.14.17 extracted from
- Squalene epoxidase as hypocholesterolemic drug target revisited (2003), Prog. Lipid Res., 42, 37-50.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (-)-epigallocatechin-3-O-gallate | - |
Rattus norvegicus |  |
| (-)-epigallocatechin-3-O-gallate | - |
Sus scrofa | |
| dodecyl gallate | - |
Rattus norvegicus | |
| dodecyl gallate | - |
Sus scrofa | |
| FR 194738 | - |
Rattus norvegicus | |
| FR 194738 | - |
Sus scrofa | |
| NB-598 | i.e. E-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bisthiophen-5-yl)methoxy]benzene-methanamine hydrochloride, potent competitive inhibitor | Rattus norvegicus | |
| NB-598 | i.e. E-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bisthiophen-5-yl)methoxy]benzene-methanamine hydrochloride, potent competitive inhibitor | Sus scrofa | |
| Pharma Project 4501 | - |
Rattus norvegicus | |
| tellurium | non-competitive inhibitor | Rattus norvegicus | |
| tellurium | non-competitive inhibitor | Sus scrofa | |
| tris norsqualene alcohol | - |
Rattus norvegicus | |
| tris norsqualene alcohol | - |
Sus scrofa | |
| tris norsqualene cyclopropylamine | - |
Rattus norvegicus | |
| tris norsqualene cyclopropylamine | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Sus scrofa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
x * 64000, SDS-PAGE | Rattus norvegicus |
| 64000 | - |
x * 64000, SDS-PAGE | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| squalene + [reduced NADPH-hemoprotein reductase] + O2 | Sus scrofa | - |
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| squalene + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 64000, SDS-PAGE | Rattus norvegicus |
| ? | x * 64000, SDS-PAGE | Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| squalene epoxidase | - |
Rattus norvegicus |
| squalene epoxidase | - |
Sus scrofa |
| squalene mono-oxygenase | - |
Rattus norvegicus |
| squalene mono-oxygenase | - |
Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| FAD | - |
Sus scrofa | |
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Sus scrofa | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
tris norsqualene cyclopropylamine | pH and temperature not specified in the publication | Sus scrofa | |
| 0.004 | - |
tris norsqualene alcohol | pH and temperature not specified in the publication | Sus scrofa | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000044 | - |
pH and temperature not specified in the publication | Rattus norvegicus | NB-598 | |
| 0.0000098 | - |
pH and temperature not specified in the publication | Sus scrofa | FR 194738 | |
| 0.000061 | - |
pH and temperature not specified in the publication | Sus scrofa | dodecyl gallate | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | squalene epoxidase inhibition may be responsible for dermatitis and neuropathy | Rattus norvegicus |
| malfunction | squalene epoxidase inhibition may be responsible for dermatitis and neuropathy | Sus scrofa |
| metabolism | the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis | Rattus norvegicus |
| metabolism | the enzyme plays a pivotal role in the maintenance of cholesterol homeostasis | Sus scrofa |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
