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Literature summary for 1.14.14.17 extracted from
- Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia (2009), Cardiol. Rev., 17, 70-76.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | possible enzyme to inhibit for treatment of hypercholesterolemia, but strong side effects (e.g. dermatitis-like toxicity) | Canis lupus familiaris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity; decreases LDL and triglyceride levels, strong side effects (e.g. dermatitis-like toxicity) | Canis lupus familiaris |  |
| NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity | Homo sapiens | |
| NB-598 | decrease of LDL and triglyceride levels, dermatitis-like toxicity | Nicotiana sp. | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + O2 + AH2 | Homo sapiens | - |
2,3 oxidosqualene + A + H2O | - |
? | |
| squalene + O2 + AH2 | Canis lupus familiaris | - |
2,3 oxidosqualene + A + H2O | - |
? | |
| squalene + O2 + AH2 | Nicotiana sp. | - |
2,3 oxidosqualene + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Nicotiana sp. | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| myoblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene + O2 + AH2 | - |
Homo sapiens | 2,3 oxidosqualene + A + H2O | - |
? | |
| squalene + O2 + AH2 | - |
Canis lupus familiaris | 2,3 oxidosqualene + A + H2O | - |
? | |
| squalene + O2 + AH2 | - |
Nicotiana sp. | 2,3 oxidosqualene + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| squalene epoxidase | - |
Homo sapiens |
| squalene epoxidase | - |
Canis lupus familiaris |
| squalene epoxidase | - |
Nicotiana sp. |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | part of cholesterol synthesis pathway | Homo sapiens |
| metabolism | part of cholesterol synthesis pathway | Canis lupus familiaris |
| metabolism | part of cholesterol synthesis pathway | Nicotiana sp. |
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