EC Number   |
Expression |
Reference |
|---|
   3.4.23.46 | down |
administration of icariin (30, 60 and 120 mg/kg) significantly reduces the contents of Abeta1-40 and the mRNA levels of beta-secretase in the hippocampus |
711927 |
| 3.4.23.46 | down |
BACE-1 activity correlates inversely with total soluble and oligomeric Abeta1-42 |
711634 |
| 3.4.23.46 | down |
BACE1 levels in 5XFAD mice are significantly increased up to 200% of those found in wild type mice |
711918 |
| 3.4.23.46 | down |
endogenous testosterone, independent of estrogen, downregulates BACE1 activities at transcriptional level. Heterozygous transgenic APP23/aromatase male mice exhibit decreased BACE1 protein expression and activity compared with control mice at age of 12 and 18 months |
712831 |
| 3.4.23.46 | down |
repression of presenilin-1 transcription by JNk inhibitor SP600125 inhibits gamma-secretase mediated processing of amyloid precursor protein |
712078 |
| 3.4.23.46 | down |
reticulon 3 is a negative modulator of BACE1 (beta-secretase) proteolytic activity |
713114 |
| 3.4.23.46 | down |
treatment with chitosan oligosaccharides (0.001-5 mg/ml) results in a dramatic reduction in enzyme mRNA level and activity |
754905 |
| 3.4.23.46 | more |
depletion of mu4 by RNAi does not alter the distribution of beta-secretase (BACE1) |
711821 |
| 3.4.23.46 | more |
mRNAand activity level of BACE1 in the cortex and hippocampus remain unchanged by dietary quercetin supplementation. Supplementing primary cortical neurons with 0.00001, 0.0001 and 0.001 mM quercetin does not result in any significant change in mRNA level of BACE |
713200 |
| 3.4.23.46 | more |
no correlation is observed between BACE-1 activity and NEP protein level |
711634 |
