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Literature summary for 3.4.23.46 extracted from

  • Dai, X.; Chang, P.; Li, X.; Gao, Z.; Sun, Y.
    The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells (2018), Neurosci. Lett., 665, 80-85 .
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
chitosan oligosaccharide IC50 of 0.098 mg/ml Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293-APPswe cell HEK-293 cell transfected with a Swedish mutant APP695 K595N/M596L Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
beta-site amyloid precursor protein cleaving enzyme 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens treatment with chitosan oligosaccharides (0.001-5 mg/ml) results in a dramatic reduction in enzyme mRNA level and activity down