Application | Comment | Organism |
---|---|---|
medicine | common or potentially functional genetic variation in BACE1 interacting proteins (reticulon 3 and peptidylprolyl isomerase (cyclophilin)-like 2) does not affect platelet membrane beta-secretase activity or contributes to risk of Alzheimer's disease in the northern Irish population | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
beta-site amyloid precursor protein cleaving enzyme | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | reticulon 3 is a negative modulator of BACE1 (beta-secretase) proteolytic activity | down |
Homo sapiens | peptidylprolyl isomerase (cyclophilin)-like 2 positively regulates BACE1 expression | up |
General Information | Comment | Organism |
---|---|---|
physiological function | BACE1 is the rate-limiting enzyme for production of beta-amyloid peptides, which are proposed to drive the pathological changes found in Alzheimer's disease | Homo sapiens |