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Literature summary for 3.4.23.46 extracted from

  • Carson, R.; McKnight, A.J.; Todd, S.; Liu, W.W.; Heggarty, S.; Craig, D.; McGuinness, B.; Irvine, G.B.; Passmore, A.P.; Johnston, J.A.
    Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to Alzheimer’s disease in the northern Irish population (2009), Neuromolecular Med., 11, 337-344.
    View publication on PubMed

Application

Application Comment Organism
medicine common or potentially functional genetic variation in BACE1 interacting proteins (reticulon 3 and peptidylprolyl isomerase (cyclophilin)-like 2) does not affect platelet membrane beta-secretase activity or contributes to risk of Alzheimer's disease in the northern Irish population Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
fragments of amyloid precursor protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
Homo sapiens fragments of amyloid precursor protein
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Homo sapiens
beta-secretase
-
Homo sapiens
beta-site amyloid precursor protein cleaving enzyme
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens reticulon 3 is a negative modulator of BACE1 (beta-secretase) proteolytic activity down
Homo sapiens peptidylprolyl isomerase (cyclophilin)-like 2 positively regulates BACE1 expression up

General Information

General Information Comment Organism
physiological function BACE1 is the rate-limiting enzyme for production of beta-amyloid peptides, which are proposed to drive the pathological changes found in Alzheimer's disease Homo sapiens