EC Number   |
Application |
Reference |
|---|
   7.6.2.1 | analysis |
assay for phospholipid flippase activities of plasma membrane-localized P4-ATPases using human cell lines stably expressing isoforms ATP8B1, ATP8B2, ATP11A, and ATP11C |
734287 |
| 7.6.2.1 | analysis |
phosphatidylserine-coumarin O-[[(2R)-2-[(9-[5-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]-1H-1,2,3-triazol-4-yl]nonanoyl)oxy]-3-(hexadecanoyloxy)propoxy](hydroxy)phosphoryl]-L-serine exhibits bright fluorescence and good photostability. It should be useful as a blue-emitting fluorescent translocation substrate for extended imaging studies of flippase action in living cells using laser confocal microscopy |
720146 |
| 7.6.2.1 | medicine |
ATP8B1 deficiency leads to reduced PS flipping and impaired farnesoid X receptor signaling via impaired PKCgamma-mediated nuclear translocation of farnesoid X receptor, resulting in reduced bile salt export pump and enhanced apical sodium-dependent bile salt transporter activation |
696442 |
| 7.6.2.1 | medicine |
some ATP8B1 mutants found in patients of progressive familial intrahepatic cholestasis type 1 (PFIC1), a severe liver disease caused by impaired bile flow, fail to translocate phosphatidylcholine despite their delivery to the plasma membrane. Incorporation of phosphatidylcholine mediated by ATP8B1 can be reversed by simultaneous expression of ABCB4, a phosphatidylcholine floppase mutated in PFIC3 patients |
734287 |
| 7.6.2.1 | medicine |
spontaneous loss of lipid asymmetry, not corrected by aminophospholipid translocase activity, is the mechanism for ribavirin-induced phosphatidylserine exposure that may contribute to ribavirin-induced anemia |
733793 |
| 7.6.2.1 | medicine |
The enzyme gene is an interesting candidate for chromosome 15-associted autism and it can contribute to the Angelman syndrome phenotype. |
654164 |
| 7.6.2.1 | molecular biology |
phosphatidylserine exposure by Tat-1 is an early in vivo marker of apoptosis in Caenorhabditis elegans |
686247 |
| 7.6.2.1 | more |
Drs2p deficiency causes a markedly increased rate of cholesterol transport from the plasma membrane to the endoplasmic reticulum and redistribution of endogenous ergosterol to intracellular membranes |
700100 |
