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Literature summary for 7.6.2.1 extracted from
- Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis (2007), Curr. Biol., 17, 994-999.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | phosphatidylserine exposure by Tat-1 is an early in vivo marker of apoptosis in Caenorhabditis elegans | Caenorhabditis elegans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knock-out of the tat-1 gene results in abolishes phosphatidylserine exposure on apoptotic cells and reduced efficiency of cell-corps clearance during embryonic development and in the hermaphrodite germ line, overview | Caenorhabditis elegans |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Caenorhabditis elegans | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Caenorhabditis elegans | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, which is a conserved event in apoptosis and plays an important role in promoting the clearance of apoptotic cells by phagocytosis, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, which is a conserved event in apoptosis and plays an important role in promoting the clearance of apoptotic cells by phagocytosis, overview | Caenorhabditis elegans | ? | - |
? | |
| additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface across the plasma membrane bilayer, overview | Caenorhabditis elegans | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid translocase | - |
Caenorhabditis elegans |
| More | the enzyme is not one of the organism's scramblases | Caenorhabditis elegans |
| P type aminophospholipid transporter | - |
Caenorhabditis elegans |
| TAT-1 | - |
Caenorhabditis elegans |
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