Literature summary for 7.6.2.1 extracted from

Kleinegris, M.C.; Koek, G.H.; Mast, K.; Mestrom, E.H.; Wolfs, J.L.; Bevers, E.M.
Ribavirin-induced externalization of phosphatidylserine in erythrocytes is predominantly caused by inhibition of aminophospholipid translocase activity (2012), Eur. J. Pharmacol., 693, 1-6.

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Application

Application	Comment	Organism
medicine	spontaneous loss of lipid asymmetry, not corrected by aminophospholipid translocase activity, is the mechanism for ribavirin-induced phosphatidylserine exposure that may contribute to ribavirin-induced anemia	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
ribavirin	prolonged treatment of erythrocytes with ribavirin results in surface exposure of phosphatidylserine, mainly caused by inactivation of the aminophospholipid translocase. Inactivation is due to severe ATP depletion	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fluorescent labeled phosphatidylserine/outer leaflet + ATP + H2O	enzyme specifically transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane	Homo sapiens	fluorescent labeled phosphatidylserine/inner leaflet + ADP + phosphate	-	?

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Release 2023.1 (January 2023)