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Literature summary for 7.6.2.1 extracted from

  • Takatsu, H.; Tanaka, G.; Segawa, K.; Suzuki, J.; Nagata, S.; Nakayama, K.; Shin, H.W.
    Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane (2014), J. Biol. Chem., 289, 33543-33556.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Application

Application Comment Organism
analysis assay for phospholipid flippase activities of plasma membrane-localized P4-ATPases using human cell lines stably expressing isoforms ATP8B1, ATP8B2, ATP11A, and ATP11C Homo sapiens
medicine some ATP8B1 mutants found in patients of progressive familial intrahepatic cholestasis type 1 (PFIC1), a severe liver disease caused by impaired bile flow, fail to translocate phosphatidylcholine despite their delivery to the plasma membrane. Incorporation of phosphatidylcholine mediated by ATP8B1 can be reversed by simultaneous expression of ABCB4, a phosphatidylcholine floppase mutated in PFIC3 patients Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens O43520
-
-
Homo sapiens P98196
-
-
Homo sapiens P98198
-
-
Homo sapiens Q8NB49
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylcholine/in
-
 Homo sapiens ADP + phosphate + phosphatidylcholine/out
-
 ?
ATP + H2O + phosphatidylcholine/in preferred substrate Homo sapiens ADP + phosphate + phosphatidylcholine/out
-
 ?
ATP + H2O + phosphatidylethanolamine/in
-
 Homo sapiens ADP + phosphate + phosphatidylethanolamine/out
-
 ?
ATP + H2O + phosphatidylserine/in
-
 Homo sapiens ADP + phosphate + phosphatidylserine/out
-
 ?
additional information no substrates: phosphatidylcholine, sphingomyelin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ATP11A
-
 Homo sapiens
ATP11C
-
 Homo sapiens
ATP8B1
-
 Homo sapiens
ATP8B2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ATPase-deficient mutants of isoform ATP11A do not exhibit any flippase activity Homo sapiens
physiological function ATPase-deficient mutants of isoform ATP11C do not exhibit any flippase activity Homo sapiens