EC Number   |
Application |
Reference |
|---|
   2.1.1.100 | analysis |
approaches to establish the quantitative structureactivity relationship of indoloacetamides as inhibitors of ICMT |
672612 |
| 2.1.1.100 | analysis |
highly sensitive capillary electrophoresis method for monitoring of the enzymic activity |
657541 |
| 2.1.1.100 | biotechnology |
the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation |
706207 |
| 2.1.1.100 | drug development |
the enzyme is a target for anticancer drug design |
706119 |
| 2.1.1.100 | medicine |
a correlation exists between p53 status and ICMT expression in breast and lung cancers. ICMT overexpression is correlated with negative clinical outcomes |
757231 |
| 2.1.1.100 | medicine |
development of Icmt inhibitors as another approach to anticancer drug development |
676786 |
| 2.1.1.100 | medicine |
generation of Icmt inhibitors based on the structure of the minimal Icmt substrate N-acetyl-S-farnesyl-L-cysteine in hopes of developing potent anticancer agents |
672603 |
| 2.1.1.100 | medicine |
ICMT loss-of-function isogenic cell lines for both RAS-transformed human mammary epithelial cells (HME1) and human cancer cell lines MiaPaca-2 and MDA-MB-231 containing naturally occurring mutant KRAS. In both in vitro and in vivo tumorigenesis studies, ICMT loss-of-function abolishes the tumor initiation ability of all major isoforms of mutant RAS in HME1 cells, and the tumor maintenance capacity of MiaPaca-2 and MDA-MB-231 cells |
757873 |
| 2.1.1.100 | medicine |
Icmt mRNA and protein levels are increased in nasopharyngeal carcinoma cells after prolonged exposure to chemotherapy. Icmt inhibition is more effective against chemoresistant compared to chemosensitive nasopharyngeal carcinoma cells. The combination of Icmt inhibition with 5-fluorouracil or cisplatin results in greater efficacy than single chemotherapeutic agent alone in nasopharyngeal carcinoma cells. Icmt inhibition decreases Ras and RhoA activities, Ras may be the critical effector of Icmt in nasopharyngeal carcinoma cells |
755981 |
| 2.1.1.100 | medicine |
inhibition of ICMT significantly reduces cell migration in vitro and cancer invasion and metastasis in vivo. The role of ICMT is mediated by regulator RAB4A. ICMT catalyzed carboxylmethylation is critical for RAB4A activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane |
757874 |
