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Literature summary for 2.1.1.100 extracted from

  • Lau, H.Y.; Tang, J.; Casey, P.J.; Wang, M.
    Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms (2017), Oncogene, 36, 3934-3942 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine ICMT loss-of-function isogenic cell lines for both RAS-transformed human mammary epithelial cells (HME1) and human cancer cell lines MiaPaca-2 and MDA-MB-231 containing naturally occurring mutant KRAS. In both in vitro and in vivo tumorigenesis studies, ICMT loss-of-function abolishes the tumor initiation ability of all major isoforms of mutant RAS in HME1 cells, and the tumor maintenance capacity of MiaPaca-2 and MDA-MB-231 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60725
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General Information

General Information Comment Organism
physiological function ICMT loss-of-function isogenic cell lines for both RAS-transformed human mammary epithelial cells (HME1) and human cancer cell lines MiaPaca-2 and MDA-MB-231 containing naturally occurring mutant KRAS. In both in vitro and in vivo tumorigenesis studies, ICMT loss-of-function abolishes the tumor initiation ability of all major isoforms of mutant RAS in HME1 cells, and the tumor maintenance capacity of MiaPaca-2 and MDA-MB-231 cells Homo sapiens