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Literature summary for 2.1.1.100 extracted from

  • Winter-Vann, A.M.; Baron, R.A.; Wong, W.; dela Cruz, J.; York, J.D.; Gooden, D.M.; Bergo, M.O.; Young, S.G.; Toone, E.J.; Casey, P.J.
    A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells (2005), Proc. Natl. Acad. Sci. USA, 102, 4336-4341.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine development of Icmt inhibitors as another approach to anticancer drug development Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cysmethynil most potent time-dependent inhibitor, inhibition of cell growth in an Icmt-dependent fashion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
-
Homo sapiens S-adenosyl-L-homocysteine + N-acetyl-S-farnesyl-L-cysteine methyl ester
-
?

Synonyms

Synonyms Comment Organism
Icmt
-
Homo sapiens
isoprenylcysteine carboxyl methyltransferase
-
Homo sapiens