Literature summary for 2.1.1.100 extracted from

Donelson, J.L.; Hodges, H.B.; Macdougall, D.D.; Henriksen, B.S.; Hrycyna, C.A.; Gibbs, R.A.
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase (2006), Bioorg. Med. Chem. Lett., 16, 4420-4423.

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Application

Application	Comment	Organism
medicine	generation of Icmt inhibitors based on the structure of the minimal Icmt substrate N-acetyl-S-farnesyl-L-cysteine in hopes of developing potent anticancer agents	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	FC analogs containing larger R-groups inhibit Icmt more effectively than those with smaller R-groups, in particular, an adamantyl analog is the most potent inhibitor. Also compounds containing 3,5-disubstituted phenyl rings, with the exception of a difluoro compound, exhibit inhibitory activity, whereas the corresponding 2,4-disubstituted analogs do not	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Icmt	-	Homo sapiens
isoprenylcysteine carboxyl methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)