EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   1.2.1.36 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
-, 390264, 390265, 390270, 390271, 390272, 390277, 655208, 655432, 655948, 656048, 689379, 690142, 693342, 696437, 762833, 762901, 763529 |
| 1.2.1.36 | cytosol |
isoforms Raldh1 and Raldh2 |
GO:0005829 AmiGO QuickGO |
725461 |
| 1.2.1.36 | cytosol |
mainly |
GO:0005829 AmiGO QuickGO |
-, 743142 |
| 1.2.1.36 | microsome |
- |
- |
-, 743142 |
| 1.2.1.36 | mitochondrial inner membrane |
outer side |
GO:0005743 AmiGO QuickGO |
686690 |
| 1.2.1.36 | mitochondrion |
- |
GO:0005739 AmiGO QuickGO |
390268, 690142, 762790 |
| 1.2.1.36 | more |
ALDH1A1 may have a broad cellular distribution in the liver, in situ hybridization |
- |
743375 |
| 1.2.1.36 | more |
although both hepatic microsomes and cytosol exhibit RALDHs enzyme activity in the presence of NADP+ or NAD+, the contribution of hepatic microsomes to all-trans retinoic acid formation is less than that of hepatic cytosol. Hepatic cytosol catalyzes the oxidation of retinal into all-trans retinoic acid with NAD+ or NADP+ as cofactor, but the cytosolic RALDHs activity prefers NAD+, evidenced by greater contribution of NAD+-dependent all-trans retinoic acid formation |
- |
-, 743142 |
| 1.2.1.36 | nucleus |
isoform Raldh1 |
GO:0005634 AmiGO QuickGO |
725461 |
| 1.2.1.36 | perinuclear space |
isoform Raldh2 |
- |
725461 |
