Application | Comment | Organism |
---|---|---|
diagnostics | ALDH1A1 is rapidly gaining importance as a stem cell marker | Rattus norvegicus |
molecular biology | ALDH1A1 is rapidly gaining importance as a stem cell marker | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
gene Aldh1a1, quantitative reverse transcription PCR enzyme expression analysis | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | ALDH1A1 may have a broad cellular distribution in the liver, in situ hybridization | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NAD+ + H2O | Rattus norvegicus | - |
all-trans-retinoate + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P51647 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | ALDH1A1 protein exhibits diffuse staining in hepatocytes, with greater intensity in the periportal region including surrounding bile ducts | Rattus norvegicus | - |
liver | ALDH1A1 is most highly expressed ALDH1 gene in liver | Rattus norvegicus | - |
macrophage | hepatic | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NAD+ + H2O | - |
Rattus norvegicus | all-trans-retinoate + NADH + 2 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH1A1 | - |
Rattus norvegicus |
RALDH | - |
Rattus norvegicus |
RALDH1A1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | inflammation reduces ALDH1A1 mRNA in whole liver regardless of the level of vitamin A in the diet, while treatment with retinal reduces ALDH1A1 expression only in chow-fed rats. Acute inflammation rapidly downregulates ALDH1A1 expression in whole liver | down |
Rattus norvegicus | acute inflammation rapidly increases the enzyme expression in periportal macrophages | up |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the ALDH1 protein family | Rattus norvegicus |
malfunction | acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages | Rattus norvegicus |
physiological function | changes in ALDH1A1 expression appear to be part of the early acute-phase inflammatory response, which alters the expression of other retinoid homeostatic genes | Rattus norvegicus |