EC Number   |
Inhibitors  |
Structure |
|---|
   3.6.5.6 | Br- |
- |
   |
| 3.6.5.6 | citral dimethyl acetal |
CDA, impairs the GTPase activity of gamma-tubulin |
|
| 3.6.5.6 | Cl- |
enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase. GTPase activity of tubulin is lower (2/3-fold) in Cl--containing solutions than that in Cl--free solutions containing Br- or NO3- |
|
| 3.6.5.6 | Colchicine |
a small molecule inhibitor that binds to tubulin dimers rendering them unable to incorporate into filaments. It does not destabilize actively, but rather inhibit repolymerization after regular depolymerization |
|
| 3.6.5.6 | curcumin |
- |
|
| 3.6.5.6 | diethyldicarbonate |
inhibits GTP hydrolysis, but not the assembly reaction |
|
| 3.6.5.6 | EDTA |
strong inhibition at 2 mM |
|
| 3.6.5.6 | GDP |
- |
|
| 3.6.5.6 | GTP |
inhibitory effect produced at concentrations above 3 mM, above 5 mM leads to depolymerization of microtubules |
|
| 3.6.5.6 | guanosine 5'-(gamma-fluorotriphosphate) |
reversible competitive dead-end inhibitor |
|
