EC Number   |
Inhibitors |
Structure |
|---|
   3.6.5.6 | Br- |
- |
   |
| 3.6.5.6 | curcumin |
- |
|
| 3.6.5.6 | GDP |
- |
|
| 3.6.5.6 | N-terminal part of stathimin like-domains |
- |
|
| 3.6.5.6 | NO3- |
- |
|
| 3.6.5.6 | vinblastine |
- |
|
| 3.6.5.6 | more |
a class of destabilizers consists of the microtubule-severing enzymes from the ATPases associated with various cellular activities (AAA+) family of ATP-enzymes. GTP-driven microtubule dynamics are coupled to ATP-driven destabilization by severing enzymes, examples and mechanism, detailed overview |
|
| 3.6.5.6 | Colchicine |
a small molecule inhibitor that binds to tubulin dimers rendering them unable to incorporate into filaments. It does not destabilize actively, but rather inhibit repolymerization after regular depolymerization |
|
| 3.6.5.6 | vinblastine |
a small molecule inhibitor that binds to tubulin dimers rendering them unable to incorporate into filaments. It does not destabilize actively, but rather inhibit repolymerization after regular depolymerization |
|
| 3.6.5.6 | citral dimethyl acetal |
CDA, impairs the GTPase activity of gamma-tubulin |
|
