EC Number   |
Activating Compound |
Reference |
|---|
   3.4.21.5 | Ca2+ |
analysis of temperature dependence of pseudo-first order rate constants for enzyme-catalyzed hydrolysis of prothrombin-derived substrates, in presence and absence of Ca2+ |
667990 |
| 3.4.21.5 | D-glucose |
high glucose enhances thrombin responses through transcriptional upregulation of protease-activated receptor-4, PAR-4, mediated via PKC-beta, -delta, and NFkappaB, in human vascular smooth muscle cells |
717167 |
| 3.4.21.5 | factor Xa |
- |
710224 |
| 3.4.21.5 | factor Xa |
active factor Xa hydrolyzes and activates prothrombin to thrombin |
708248 |
| 3.4.21.5 | factor Xa |
coagulation factor Xa activates thrombin in ischemic neural tissue |
709601 |
| 3.4.21.5 | gamma' peptide |
extensive interactions between thrombin and the gamma' peptide mediated by electrostatic contacts with residues of exosite II and hydrophobic interactions with a pocket in close proximity to the Na+ binding site, complex structure and binding mode, the gamma' peptide completely overlaps with heparin bound to exosite II, overview |
683254 |
| 3.4.21.5 | glycerol |
increases deacylation rate with p-nitrophenyl-p'-guanidinobenzoate |
95535 |
| 3.4.21.5 | heparin |
extensive interactions between thrombin and the gamma' peptide mediated by electrostatic contacts with residues of exosite II and hydrophobic interactions with a pocket in close proximity to the Na+ binding site, complex structure and binding mode, the gamma' peptide completely overlaps with heparin bound to exosite II, overview |
683254 |
| 3.4.21.5 | lung thromboplastin activator |
the activation of bovine prothrombin occurs by bovine lung thromboplastin activator |
708152 |
| 3.4.21.5 | more |
defibrination of plasma results in an increased rate of thrombin generation |
653972 |
