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Literature summary for 3.4.21.5 extracted from

  • de Bosch, N.B.; Mosesson, M.W.; Ruiz-Saez, A.; Echenagucia, M.; Rodriguez-Lemoin, A.
    Inhibition of thrombin generation in plasma by fibrin formation (antithrombin I) (2002), Thromb. Haemost., 88, 253-258.
    View publication on PubMed
Search for more literature for 3.4.21.5

Activating Compound

Activating Compound Comment Organism Structure
additional information defibrination of plasma results in an increased rate of thrombin generation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information defective mutant enzymes of 2 humans with congenital afibrinogenemia, termed MC and KU, show impaired binding of thrombin to the thrombin binding sites of fibrin and fibrin gamma' peptides, respectively Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fibrinogen 1 down-regulation of thrombin production Homo sapiens
fibrinogen 2 more potent inhibition compared to fibrinogen 1, down-regulation of thromin production Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen 1 + H2O Homo sapiens
-
 fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
 ?
fibrinogen 2 + H2O Homo sapiens
-
 fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
 ?
additional information Homo sapiens enzyme deficienxy leads to umbilical cord bleeding at birth, development of hematoma, diminished vitamin K-dependent clotting factor, thrombocytopenia, and at least to lethal retroperitoneal bleeding ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 enzyme from platelet-poor plasma of 2 humans with congenital afibrinogenemia, termed MC and KU
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma platelet-poor Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
fibrinogen 1 + H2O
-
 Homo sapiens fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
 ?
fibrinogen 2 + H2O
-
 Homo sapiens fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
 ?
additional information enzyme deficienxy leads to umbilical cord bleeding at birth, development of hematoma, diminished vitamin K-dependent clotting factor, thrombocytopenia, and at least to lethal retroperitoneal bleeding Homo sapiens ?
-
 ?