Literature summary for 3.4.21.5 extracted from

Fasco, M.J.; Fenton II, J.W.
Specificity of thrombin. I. Esterolytic properties of thrombin, plasma, trypsin, and chymotrypsin with Nbeta-substituted guanidino derivatives of p-nitrophenyl-p'-guanidinobenzoate (1973), Arch. Biochem. Biophys., 159, 802-812.

No PubMed abstract available

Search for more literature for 3.4.21.5

Activating Compound

Activating Compound	Comment	Organism	Structure
glycerol	increases deacylation rate with p-nitrophenyl-p'-guanidinobenzoate	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
glycerol	decreases cleavage rates with n-butyl derivatives	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p-nitrophenyl-p'-(Nbeta,n-butyl-Nalpha-guanidino)benzoate + H2O	-	Homo sapiens	?	-	?
p-nitrophenyl-p'-(Nbeta,n-hexyl-Nalpha-guanidino)benzoate + H2O	-	Homo sapiens	?	-	?
p-nitrophenyl-p'-guanidinobenzoate + H2O	-	Homo sapiens	?	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.00102	-	p-nitrophenyl-p'-(Nbeta,n-butyl-Nalpha-guanidino)benzoate	-	Homo sapiens
0.0018	-	p-nitrophenyl-p'-guanidinobenzoate	-	Homo sapiens
0.00197	-	p-nitrophenyl-p'-(Nbeta,n-hexyl-Nalpha-guanidino)benzoate	-	Homo sapiens

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Release 2023.1 (January 2023)