Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.5 extracted from

  • Turpie, A.G.
    Direct Factor Xa and direct thrombin inhibitors: a clinical trial update (2009), Curr. Opin. Drug Discov. Devel., 12, 497-508.
    View publication on PubMed
Search for more literature for 3.4.21.5

Activating Compound

Activating Compound Comment Organism Structure
factor Xa active factor Xa hydrolyzes and activates prothrombin to thrombin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ARH-067637 the prodrug AZD-0837 is bioactively converted into the direct thrombin inhibitor ARH-067637 Homo sapiens
AZD-0837 direct thrombin inhibitor, the prodrug AZD-0837 is bioactively converted into the direct thrombin inhibitor ARH-067637 Homo sapiens
dabigatran specific, competitive and reversible inhibitor of thrombin, dabigatran binds to the active site of thrombin via hydrophobic interactions and can inhibit both free and fibrin-bound thrombin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000045
-
 dabigatran
-
 Homo sapiens