EC Number   |
Activating Compound |
Reference |
|---|
   3.4.21.38 | more |
conformational change ion factor XII is a key event in the activation process of this molecule. This conformational change can be induced by binding of factor XII to a surface as well as by proteolytic cleavage. Monoclonal antibody F1 can also induce the conformational change, this antibody may provide a unique tool in studies of the activation of factor XII |
95418 |
| 3.4.21.38 | more |
exposure of blood to foreign surfaces induces reciprocal conversion of factor XII to the active protease alpha-fXIIa. These so-called contact activation is initiated through activity intrinsic to single-chain factor XII. Pre-existing alpha-fXIIa is not required for induction of contact activation |
753351 |
| 3.4.21.38 | more |
extracellular RNA, but not DNA, augments (auto)activation of FXII and thereby acts as a potent trigger of coagulation in vivo |
696939 |
| 3.4.21.38 | more |
Factor XII autoactivation is also initiated by misfolded or amorphous protein aggregates of transthyretin, Bence-Jones protein, glycated albumin, glycated hemoglobin, or endostatin |
699180 |
| 3.4.21.38 | more |
factor XIIa undergoes large changes in secondary structures when exposed to low pH in the presence of dextran sulfate 500. The reaction of factor XII with dextran sulfate 500 at pH 5.3 results in loss of alpha-helical structure while at pH 8.3, in its formation. At pH 5.3 autoactivation is inhibitited. This may indicate that alpha-helical structure in factor XII plays an important role in the autoactivation mechanism |
95420 |
| 3.4.21.38 | more |
platelet- and erythrocyte-derived microparticles initiate the formation of thrombin via the activation of factor XII |
732402 |
| 3.4.21.38 | more |
the enzyme gets activated by contact when exposed to artificial surfaces and biological substances |
753067 |
| 3.4.21.38 | more |
the enzyme is activated when blood is exposed to negatively-charged foreign surfaces or molecules such as RNA, DNA, misfolded proteins, and polyphosphates |
752492 |
| 3.4.21.38 | plasma kallikrein |
- |
699180 |
| 3.4.21.38 | plasma kallikrein |
factor XII is activated by plasma kallikrein in the presence of kaolin and high molecular weight kininogen stimulates the activation 4fold to 5fold. Factor XII is also activated by plasma kallikrein in the presence of vesicles of acidic lipids, such as sulfatides, ganglioside, stearic acid, and cholesterol sulfate |
95423 |
