Literature summary for 3.4.21.38 extracted from

Nuijens, J.H.; Huijbregts, C.C.M.; Eerenberg-Belmer, A.J.M.; Meijers, J.C.M.; Bouma, B.N.; Hack, C.E.
Activation of the contact system of coagulation by a monoclonal antibody directed against a neodeterminant in the heavy chain region of human coagulation factor XII (Hageman factor) (1989), J. Biol. Chem., 264, 12941-12949.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	conformational change ion factor XII is a key event in the activation process of this molecule. This conformational change can be induced by binding of factor XII to a surface as well as by proteolytic cleavage. Monoclonal antibody F1 can also induce the conformational change, this antibody may provide a unique tool in studies of the activation of factor XII	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)