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Literature summary for 3.4.21.38 extracted from

  • Schmaier, A.H.
    The elusive physiologic role of Factor XII (2008), J. Clin. Invest., 118, 3006-3009.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.38

Activating Compound

Activating Compound Comment Organism Structure
kaolin
-
 Homo sapiens
additional information Factor XII autoactivation is also initiated by misfolded or amorphous protein aggregates of transthyretin, Bence-Jones protein, glycated albumin, glycated hemoglobin, or endostatin Homo sapiens
plasma kallikrein
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FXII autoactivates by contact with a variety of artificial or biologic negatively charged surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kallikrein-kinin and complement systems ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C1 esterase + H2O
-
 Homo sapiens activated C1 esterase
-
 ?
factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?
additional information FXII autoactivates by contact with a variety of artificial or biologic negatively charged surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kallikrein-kinin and complement systems Homo sapiens ?
-
 ?
prekallikrein + H2O
-
 Homo sapiens activated prekallikrein
-
 ?

Synonyms

Synonyms Comment Organism
alpha-FXIIa
-
 Homo sapiens
beta-FXIIa alpha-FXIIa when cleaved by plasma kallikrein forms Factor beta-XIIa Homo sapiens
factor XII
-
 Homo sapiens
FXII
-
 Homo sapiens
FXIIa activated factor XII Homo sapiens
Hageman factor
-
 Homo sapiens