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Literature summary for 3.4.21.38 extracted from
- Single-chain factor XII a new form of activated factor XII (2017), Curr. Opin. Hematol., 24, 411-418 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | exposure of blood to foreign surfaces induces reciprocal conversion of factor XII to the active protease alpha-fXIIa. These so-called contact activation is initiated through activity intrinsic to single-chain factor XII. Pre-existing alpha-fXIIa is not required for induction of contact activation | Homo sapiens | |
| Polyphosphate | - |
Homo sapiens |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R334A/R344A/R353A | in the presence of polyphosphate, the mutant converts factor XII to its active form alpha-fXIIa, and also converts factor XI to its active form fXIa. The mutant does not undergo autocatalysis to alpha-fXIIa in the presence of polyphosphate, and is resistant to cleavage by alpha-kallikrein and factor XIIa | Homo sapiens |
| S554A | inactive | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | Homo sapiens | - |
factor XIa + ? | - |
? | |
| plasma prekallikrein + H2O | Homo sapiens | - |
plasma kallikrein + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | - |
Homo sapiens | factor XIa + ? | - |
? | |
| factor XII + H2O | the enzyme undergoes autoactivation to alpha-fXIIa in the presence of polyphosphate | Homo sapiens | factor XIIa + ? | - |
? | |
| plasma prekallikrein + H2O | - |
Homo sapiens | plasma kallikrein + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 80000, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activated factor XII | - |
Homo sapiens |
| alpha-FXIIa | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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