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Information on EC 4.2.1.12 - phosphogluconate dehydratase
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EC Tree
4.2.1.12 phosphogluconate dehydrataseSpecify your search results
Word Map
- 4.2.1.12
-
entner-doudoroff
- aldolase
- 2-keto-3-deoxy-6-phosphogluconate
- glucose-6-phosphate
- mobilis
-
zymomonas
- kdpg
- gluconokinase
-
4.1.2.14
-
1.1.1.44
- synthesis
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
6-phosphogluconate dehydratase, phosphogluconate dehydratase, edd protein, 6-phosphogluconate dehydrase, gluconate 6-phosphate dehydratase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
6-PG dehydrase
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6-phosphogluconate dehydrase
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6-phosphogluconate dehydratase
6-phosphogluconic dehydrase
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6PGDT
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dehydratase, phosphogluconate
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EDD
Edd protein
gluconate 6-phosphate dehydratase
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gluconate-6-phosphate dehydratase
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6-phosphogluconate dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
mechanism: 6-phosphogluconate is dehydrated to form enol-2-keto-3-deoxy-6-phosphogluconate, which is spontaneously ketonized
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6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
mechanism: 6-phosphogluconate is dehydrated to form enol-2-keto-3-deoxy-6-phosphogluconate, which is spontaneously ketonized
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6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
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-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
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CAS REGISTRY NUMBER
COMMENTARY
9024-33-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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multicopy plasmid suppression of stationary phase chaperone toxicity in E. coli by phosphogluconate dehydratase and the N-terminus of DnaK
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?
6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
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?
6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Bradyrhizobium lupini RL3001
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
-
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
-
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Methylophilus methanolovorus
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Protaminobacter candidus
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
mutants deficient of 6-phosphogluconate dehydratase grow on succinate but not on glucose, role of 6-phosphogluconate dehydratase in metabolism during root colonisation and induction of systemic resistance
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
mutants deficient of 6-phosphogluconate dehydratase grow on succinate but not on glucose, role of 6-phosphogluconate dehydratase in metabolism during root colonisation and induction of systemic resistance
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Pseudomonas mildenbergii
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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ir
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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-
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
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?
6-phospho-D-gluconate
?
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key enzyme of the pentose phosphate pathway and the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
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the enzyme is significantly induced at all stages of growth assayed
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?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
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enzyme of the Entner-Doudoroff pathway
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
multicopy plasmid suppression of stationary phase chaperone toxicity in E. coli by phosphogluconate dehydratase and the N-terminus of DnaK
-
-
?
6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
-
-
-
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?
6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
-
-
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O
Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
key enzyme of the pentose phosphate pathway and the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
the enzyme is significantly induced at all stages of growth assayed
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
6-phospho-D-gluconate
?
-
enzyme of the Entner-Doudoroff pathway
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe2+
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completely inactive in absence of divalent metal ion, Fe2+ is most effective
Iron
Mg2+
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completely inactive in absence of divalent metal ion, 45% of the activation by Fe2+
Mn2+
Iron
-
Fe-S protein. 6-Phosphogluconate dehydratase activity is reduced during iron starvation in suf mutant. The de novo synthesis of the 4Fe-4S cluster in phosphogluconate dehydratase is impaired in the sufABCDSE mutant strain under iron starvation conditions
Mn2+
-
completely inactive in absence of divalent metal ion, 70% of the activation by Fe2+
Mn2+
-
the enzyme contains one Mn2+ per subunit, which is essential for activity, may be involved in binding of the substrate
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
glycerophosphates
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most strongly inhibited by the D-alpha-isomer which structurally corresponds to half of the substrate molecule
-
O2-
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the O2--sensitive target site is proposed to be an iron-sulfur cluster which is readily destroyed by oxidation
additional information
transcription of the edd gene and bacterial growth is lower if succinate is the sole carbon source, the edd mutant of Pseudomonas chlororaphis O6 fails to grow on glucose media
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additional information
-
transcription of the edd gene and bacterial growth is lower if succinate is the sole carbon source, the edd mutant of Pseudomonas chlororaphis O6 fails to grow on glucose media
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
transcription of the edd gene is higher in media containing glucose than with organic acids
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additional information
-
transcription of the edd gene is higher in media containing glucose than with organic acids
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Progestin-inducible EDD E3 ubiquitin ligase binds to ?4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
phosphogluconate dehydratase deficiency
6-Phosphogluconate dehydratase deficiency in pleiotropic carbohydrate-negative mutant strains of Pseudomonas aeruginosa.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
effects of different carbon sources on expression and growth studied in wild-type bacteria and in mutans deficient of 6-phosphogluconate dehydratase, late-stage root colonisation affected, 6-phosphogluconate dehydratase involved in maintainance of Pseudomonas populations in the rhizospere
additional information
-
effects of different carbon sources on expression and growth studied in wild-type bacteria and in mutans deficient of 6-phosphogluconate dehydratase, late-stage root colonisation affected, 6-phosphogluconate dehydratase involved in maintainance of Pseudomonas populations in the rhizospere
additional information
-
coupled reaction of EC 4.2.1.12 plus EC 4.1.2.14
additional information
-
coupled reaction of EC 4.2.1.12 plus EC 4.1.2.14
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain Y1, strain Y2, strain Y6, strain S91, strain S85, strain M132
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-
brenda
rhizobacterium, wild-type and mutants of the edd gene encoding 6-phosphogluconate dehydratase
SwissProt
brenda
rhizobacterium, wild-type and mutants of the edd gene encoding 6-phosphogluconate dehydratase
SwissProt
brenda
6-phosphogluconate dehydratase activity is reduced during iron starvation in suf mutant
-
-
brenda
wild type strain constitutively synthesizes this enzyme, mutant strain inducibly forms the enzyme
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
rhizophere of Nicotiana tabacum Xanthi hosts the rhizobacterium Pseudomonas chlororaphis O6, effects of 6-phosphogluconate dehydratase on root colonisation and induction of systemic resistance by Pseudomonas chlororaphis 06 analyzed
brenda
-
rhizophere of Nicotiana tabacum Xanthi hosts the rhizobacterium Pseudomonas chlororaphis O6, effects of 6-phosphogluconate dehydratase on root colonisation and induction of systemic resistance by Pseudomonas chlororaphis 06 analyzed
-
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
-
inactivation of 6-phosphogluconate dehydratase gene does increase intracellular D-glucose 6-phosphate and xanthan production