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BRENDA support

Ligand 6-phosphogluconate

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Basic Ligand Information

Molecular Structure
Picture of 6-phosphogluconate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O10P
6-phosphogluconate
BIRSGZKFKXLSJQ-SQOUGZDYSA-N
Synonyms:
6-O-phosphono-D-gluconic acid, 6-phosphgluconate, 6-phospho-D-gluconate, 6-phospho-gluconate, 6-phosphogluconic acid, D-6-phosphogluconate, D-gluconate 6-phosphate, gluconate 6-phosphate, phosphogluconate
Pathway Source
Pathways
BRENDA
Entner Doudoroff pathway, ketogluconate metabolism, pentose phosphate pathway
KEGG
Biosynthesis of secondary metabolites, Carbon metabolism, Microbial metabolism in diverse environments, Pentose phosphate pathway
MetaCyc
D-gluconate degradation, Entner-Doudoroff pathway I, Entner-Doudoroff shunt, formaldehyde oxidation I, glucose degradation (oxidative) more


Show all pahtways known for Show all BRENDA pathways known for 6-phosphogluconate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (16 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-phospho-D-gluconate + NAD+ = D-ribulose 5-phosphate + CO2 + NADH + H+
show the reaction diagram
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6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (87 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-phospho-D-gluconate + H2O = D-gluconate + phosphate
show the reaction diagram
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6-phosphogluconate + H2O = ?
show the reaction diagram
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6-phospho-D-gluconate + H2O = D-gluconate + phosphate
show the reaction diagram
-
6-phosphogluconate + H2O = gluconate + phosphate
show the reaction diagram
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D-gluconate 6-phosphate + H2O = D-gluconate + phosphate
show the reaction diagram
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6-phosphogluconate + H2O = gluconate + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (19 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-phospho-2-dehydro-D-gluconate + NAD(P)H = 6-phospho-D-gluconate + NAD(P)+
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (13 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.005 mM slightly stimulates chloroplastic form
-
slight activation
-
activates
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Inhibitor in Enzyme-catalyzed Reactions (79 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
cytosolic isozyme
-
reaction intermediate
-
isoenzyme I, french bean
-
slight
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alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
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5 mM, 9% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (123 results)

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EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
325
-
with NADP+ as cosubstrate, in 50 mM HEPES buffer (pH 7.5), at 80°C

KM Value (125 results)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.64
-
pH 8.5, 38°C
2.7
-
in 25 mM HEPES, pH 7.4, 25 mM KCl, 1 mM MgCl2, 1 mM dithiothreitol, at 37°C
0.59
-
25°C, pH 5.6

Ki Value (26 results)

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EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.05
-
at pH 8.0 and 25°C
0.0136
-
Kis, variable substrate D-glucose 6-phosphate
0.08
-
-

References & Links

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Links to other databases for 6-phosphogluconate

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ChEBI
PubChem
ChEBI
PubChem