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IUBMB Comments The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions.
Synonyms
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beta-glycosyltransferase
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D-glycosyltransferase
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exo-beta-glycosyltransferase
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glycose transferase
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raucaffricine beta-D-glucosidase
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raucaffricine beta-glucosidase
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raucaffricine O-beta-D-glucosidase
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UDPG:vomilenine 21-beta-D-glycosyltransferase
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vomilenine glycosyltransferase
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UDP-glucose + vomilenine = UDP + raucaffricine
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glycosyl group transfer
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MetaCyc
ajmaline and sarpagine biosynthesis
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UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase
The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions.
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strictosidine + UDP
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Substrates: recombinant enzyme
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UDP-glucose + vomilenine
UDP + raucaffricine
UDP-glucose + vomilenine
UDP + raucaffricine
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Substrates: -
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UDP-glucose + vomilenine
UDP + raucaffricine
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Substrates: -
r
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UDP-glucose + vomilenine
UDP + raucaffricine
UDP-glucose + vomilenine
UDP + raucaffricine
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Substrates: -
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UDP-glucose + vomilenine
UDP + raucaffricine
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Substrates: -
r
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(phenylmethyl)sulfonyl fluoride
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strong inhibition at 10 mM
1,10-phenanthroline
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strong inhibition at 5 mM
5,5'-dithiobis(2-nitrobenzoic acid)
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strong inhibition at 1.25 mM
Cu2+
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complete inhibition at 10 mM
EDTA
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strong inhibition at 5 mM
Fe3+
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complete inhibition at 10 mM
Hg2+
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complete inhibition at 10 mM
p-Hydroxybenzaldehyde
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strong inhibition at 5 mM
Zn2+
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complete inhibition at 10 mM
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Diabetes Mellitus
Effects of transglucosidase on diabetes, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled trial.
Diabetes Mellitus
Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double-blind, placebo-controlled study.
Diabetes Mellitus
Transglucosidase improves the gut microbiota profile of type 2 diabetes mellitus patients: a randomized double-blind, placebo-controlled study.
Diabetes Mellitus, Type 2
Effects of transglucosidase on diabetes, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled trial.
Diabetes Mellitus, Type 2
Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double-blind, placebo-controlled study.
Diabetes Mellitus, Type 2
Transglucosidase improves the gut microbiota profile of type 2 diabetes mellitus patients: a randomized double-blind, placebo-controlled study.
Gaucher Disease
Human glucocerebrosidase mediates formation of xylosyl-cholesterol by ?-xylosidase and transxylosidase reactions.
Hyperglycemia
Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs.
Movement Disorders
Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double-blind, placebo-controlled study.
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additional information
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52 pkat/mg
additional information
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538 pkat/mg
additional information
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469 nkat/mg
additional information
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0.5 µkat/mg
additional information
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2.6 nkat/mg
additional information
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136 pkat/mg
additional information
Rauwolfia caffra
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253 pkat/mg
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brenda
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brenda
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brenda
Rauwolfia caffra
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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additional information
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no glycosylation
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55
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30 min, 50% of activity left
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2-mercaptoethanol stabilizes transferase activity
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ascorbic acid stabilizes transferase activity
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dithioerythritol stabilizes transferase activity
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-20°C, 3 weeks, no loss in activity
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4°C, 6 month, 30% loss in activity
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expression in Escherichia coli
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Schuebel, H.; Stoeckigt, J.; Feicht, R.; Simon, H.
Partial purification and characterization of raucaffricine beta-D-glucosidase from plant cell-suspension cultures of Rauwolfia serpentina Benth
Helv. Chim. Acta
69
538-547
1986
Rauvolfia mannii, Rauvolfia serpentina, Rauvolfia verticillata, Rauwolfia caffra
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brenda
Ruyter, C.M.; Stoeckigt, J.H.H.
Enzymatic formation of Raucaffricine, the major indole alkaloid of Rauwolfia serpentina cell-suspension cultures
Helv. Chim. Acta
74
1707-1712
1991
Rauvolfia serpentina
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brenda
Lutterbach, R.; Ruyter, C.M.; Stoeckigt, J.
Isolation and characterization of an UDPG-dependent glucosyltransferase activity from Rauwolfia serpentina Benth. cell suspension cultures
Can. J. Chem.
72
51-55
1994
Rauvolfia serpentina
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brenda
Warzecha, H.; Obitz, P.; Stockigt, J.
Purification, partial amino acid sequence and structure of the product of raucaffricine-O-beta-D-glucosidase from plant cell cultures of Rauwolfia serpentina
Phytochemistry
50
1099-1109
1999
Rauvolfia serpentina
brenda
Warzecha, H.; Gerasimenko, I.; Kutchan, T.M.; Stockigt, J.
Molecular cloning and functional bacterial expression of a plant glucosidase specifically involved in alkaloid biosynthesis
Phytochemistry
54
657-666
2000
Rauvolfia serpentina
brenda
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