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Information on EC 2.3.1.287 - phthioceranic/hydroxyphthioceranic acid synthase

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IUBMB Comments
This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation .
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The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Reaction Schemes
8
+
palmitoyl-[(hydroxy)phthioceranic acid synthase]
+
16
+
16
=
8
+
C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase]
+
16
+
8
+
8
7
+
palmitoyl-[(hydroxy)phthioceranic acid synthase]
+
14
+
14
=
7
+
C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase]
+
14
+
7
+
7
Synonyms
msl2, Pks2, polyketide synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH + 14 H+ = 7 CO2 + C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP+ + 7 CoA + 7 H2O
show the reaction diagram
(2)
-
-
-
8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH + 16 H+ = 8 CoA + C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP+ + 8 CO2 + 8 H2O
show the reaction diagram
(1)
-
-
-
PATHWAY SOURCE
PATHWAYS
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