This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation .
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The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation [2].
a pks2 gene disruption mutant is incapable of producing hepta- and octamethyl phthioceranic acids and hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids. Consequently, the pks2 mutant does not produce sulfolipids
a pks2 gene disruption mutant is incapable of producing hepta- and octamethyl phthioceranic acids and hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids. Consequently, the pks2 mutant does not produce sulfolipids; strains with a disruption of the pks2 gene do not synthesize sulfolipids
the enzyme is required for sulfolipid biosynthesis and synthesizes phthioceronic acids and hydroxyphthioceronic acids as the major components of mycobacterial sulfolipids
Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions
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Enzyme Nomenclature
2.3.1.287 phthioceranic/hydroxyphthioceranic acid synthase
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