Reference on EC 2.1.1.233 - [phosphatase 2A protein]-leucine-carboxy methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tolstykh, T.; Lee, J.; Vafai, S.; Stock, J.B.
Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
EMBO J.
19
5682-5691
2000
Bos taurus
Tsai, M.; Cronin, N.; Djordjevic, S.
The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A
Acta Crystallogr. Sect. D
67
14-24
2011
Homo sapiens
De Baere, I.; Derua, R.; Janssens, V.; Van Hoof, C.; Waelkens, E.; Merlevede, W.; Goris, J.
Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue
Biochemistry
38
16539-16547
1999
Homo sapiens, Sus scrofa
Longin, S.; Zwaenepoel, K.; Martens, E.; Louis, J.; Rondelez, E.; Goris, J.; Janssens, V.
Spatial control of protein phosphatase 2A (de)methylation
Exp. Cell Res.
314
68-81
2008
Homo sapiens
Xie, H.; Clarke, S.
Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain
J. Biol. Chem.
269
1981-1984
1994
Bos taurus
Wei, H.; Ashby, D.; Moreno, C.; Ogris, E.; Yeong, F.; Corbett, A.; Pallas, D.
Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p
J. Biol. Chem.
276
1570-1577
2001
Saccharomyces cerevisiae
Leulliot, N.; Quevillon-Cheruel, S.; Sorel, I.; De La Sierra-Gallay, I.; Collinet, B.; Graille, M.; Blondeau, K.; Bettache, N.; Poupon, A.; Janin, J.; Van Tilbeurgh, H.
Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity
J. Biol. Chem.
279
8351-8358
2004
Saccharomyces cerevisiae (Q04081), Saccharomyces cerevisiae
Lee, J.; Pallas, D.
Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells
J. Biol. Chem.
282
30974-30984
2007
Homo sapiens, Mus musculus
Sontag, J.; Nunbhakdi-Craig, V.; Mitterhuber, M.; Ogris, E.; Sontag, E.
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells
J. Neurochem.
115
1455-1465
2010
Mus musculus
Stanevich, V.; Jiang, L.; Satyshur, K.; Li, Y.; Jeffrey, P.; Li, Z.; Menden, P.; Semmelhack, M.; Xing, Y.
The structural basis for tight control of PP2A methylation and function by LCMT-1
Mol. Cell.
41
331-342
2011
Homo sapiens
DeGrande, S.; Little, S.; Nixon, D.; Wright, P.; Snyder, J.; Dun, W.; Murphy, N.; Kilic, A.; Higgins, R.; Binkley, P.; Boyden, P.; Carnes, C.; Anderson, M.; Hund, T.; Mohler, P.
Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart
J. Biol. Chem.
288
1032-1046
2013
Homo sapiens
Longman, M.; Ranieri, A.; Avkiran, M.; Snabaitis, A.
Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes
PLoS ONE
9
e86234
2014
Rattus norvegicus (Q6P4Z6), Rattus norvegicus Wistar (Q6P4Z6)
Xia, X.; Gholkar, A.; Senese, S.; Torres, J.Z.
A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size
Cell Cycle
14
1938-1947
2015
Homo sapiens
Sontag, J.M.; Nunbhakdi-Craig, V.; Sontag, E.
Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells
J. Biol. Chem.
288
27396-27405
2013
Homo sapiens
MacKay, K.B.; Tu, Y.; Young, S.G.; Clarke, S.G.
Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling
PLoS ONE
8
e65967
2013
Mus musculus
Tian, H.; Lu, Y.; Liu, J.; Liu, W.; Lu, L.; Duan, C.; Gao, G.; Yang, H.
Leucine carboxyl methyltransferase downregulation and protein phosphatase methylesterase upregulation contribute toward the inhibition of protein phosphatase 2A by alpha-synuclein
Front. Aging Neurosci.
10
173
2018
Mus musculus (A0A0U1RNF2), Mus musculus, Mus musculus C57BL/6N (A0A0U1RNF2)
Hwang, J.; Lee, J.A.; Pallas, D.C.
Leucine carboxyl methyltransferase 1 (LCMT-1) methylates protein phosphatase 4 (PP4) and protein phosphatase 6 (PP6) and differentially regulates the stable formation of different PP4 holoenzymes
J. Biol. Chem.
291
21008-21019
2016
Mus musculus (A2RTH5), Mus musculus
Nicholls, R.E.; Sontag, J.M.; Zhang, H.; Staniszewski, A.; Yan, S.; Kim, C.Y.; Yim, M.; Woodruff, C.M.; Arning, E.; Wasek, B.; Yin, D.; Bottiglieri, T.; Sontag, E.; Kandel, E.R.; Arancio, O.
PP2A methylation controls sensitivity and resistance to beta-amyloid-induced cognitive and electrophysiological impairments
Proc. Natl. Acad. Sci. USA
113
3347-3352
2016
Mus musculus (A2RTH5), Mus musculus
Palanichamy, K.; Kanji, S.; Gordon, N.; Thirumoorthy, K.; Jacob, J.R.; Litzenberg, K.T.; Patel, D.; Chakravarti, A.
NNMT silencing activates tumor suppressor PP2A, inactivates oncogenic STKs, and inhibits tumor forming ability
Clin. Cancer Res.
23
2325-2334
2017
Homo sapiens (Q9UIC8)
Park, H.J.; Lee, K.W.; Oh, S.; Yan, R.; Zhang, J.; Beach, T.G.; Adler, C.H.; Voronkov, M.; Braithwaite, S.P.; Stock, J.B.; Mouradian, M.M.
Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease
J. Neuropathol. Exp. Neurol.
77
139-148
2018
Homo sapiens (Q9UIC8)
Creighton, M.T.; Kolton, A.; Kataya, A.R.A.; Maple-Grodem, J.; Averkina, I.O.; Heidari, B.; Lillo, C.
Methylation of protein phosphatase 2A - influence of regulators and environmental stress factors
Plant Cell Environ.
40
2347-2358
2017
Arabidopsis thaliana (Q8VY08), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q8VY08)
Dudiki, T.; Kadunganattil, S.; Ferrara, J.; Kline, D.; Vijayaraghavan, S.
Changes in carboxy methylation and tyrosine phosphorylation of protein phosphatase PP2A are associated with epididymal sperm maturation and motility
PLoS ONE
10
e0141961
2015
Mus musculus (A0A0U1RNF2), Bos taurus (Q3T0H0)
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