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Information on EC 1.2.98.1 - formaldehyde dismutase

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EC Tree
     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
            
                1.2.98.1 formaldehyde dismutase
IUBMB Comments
The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) . Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
aldehyde dismutase, cannizzanase, dismutase, formaldehyde, FDM, N,N9-dimethyl-4-nitrosoaniline oxidoreductase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
2 formaldehyde + H2O = formate + methanol
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