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Information on EC 1.14.15.38 - N,N-dimethyl phenylurea N-demethylase

for references in articles please use BRENDA:EC1.14.15.38
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IUBMB Comments
The enzyme, found in members of the Sphingobium genus, initiates the degradation of N,N-dimethyl-phenylurea herbicides by mono-N-demethylation. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The enzyme associates with additional proteins (a reductase and a [3Fe-4S] type ferredoxin) that are involved in the transfer of electrons from NAD(P)H to the active site.
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Word Map
The expected taxonomic range for this enzyme is: Sphingobium sp. YBL2
Reaction Schemes
an N,N-dimethyl-N'-phenylurea compound
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2
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2
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=
an N-methyl-N'-phenylurea compound
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+
2
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an N,N-dimethyl-N'-phenylurea compound
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2
reduced ferredoxin [iron-sulfur] cluster
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2
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=
an N-methyl-N'-phenylurea compound
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+
2
oxidized ferredoxin [iron-sulfur] cluster
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Synonyms
pdmAB, PudmA, PudmB, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an N,N-dimethyl-N'-phenylurea compound + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = an N-methyl-N'-phenylurea compound + formaldehyde + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
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