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IUBMB Comments A cytochrome P-450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters .
The enzyme appears in viruses and cellular organisms
Synonyms
6beta-hydroxylase, cyp3a10, lithocholate 6beta-hydroxylase,
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3A10/lithocholic acid 6beta-hydroxylase
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cytochrome P450 3A10/lithocholic acid
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cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase
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lithocholate 6beta-monooxygenase
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lithocholic acid 6beta-hydroxylase
lithocholic acid 6beta-hydroxylase
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lithocholic acid 6beta-hydroxylase
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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lithocholate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (6beta-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1].
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
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hydroxylations of bile acids by reconstituted systems from rat liver microsomes
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
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cytochrome P-450
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brenda
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expressed only in male
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expression of CYP 3A10 protein is male-specific in hamster liver microsome
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male-specific enzyme
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male-specific enzyme. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene
brenda
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brenda
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brenda
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expression of CYP 3A10 protein is male-specific in hamster liver microsome
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brenda
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brenda
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CP3AA_MESAU
503
2
57693
Swiss-Prot
Secretory Pathway (Reliability: 1 )
B7QJP2_IXOSC
244
1
28765
TrEMBL
Mitochondrion (Reliability: 4 )
B7PWD0_IXOSC
221
1
25004
TrEMBL
other Location (Reliability: 5 )
B7P3G9_IXOSC
252
0
29237
TrEMBL
Mitochondrion (Reliability: 2 )
E0V9X5_PEDHC
Pediculus humanus subsp. corporis
414
0
47052
TrEMBL
other Location (Reliability: 2 )
B7QDA2_IXOSC
141
1
16573
TrEMBL
Secretory Pathway (Reliability: 2 )
B7P5J2_IXOSC
121
0
13790
TrEMBL
Mitochondrion (Reliability: 5 )
E0VRD2_PEDHC
Pediculus humanus subsp. corporis
526
1
61291
TrEMBL
Secretory Pathway (Reliability: 2 )
B7PIN7_IXOSC
312
0
35549
TrEMBL
other Location (Reliability: 3 )
B7QI39_IXOSC
102
0
11484
TrEMBL
other Location (Reliability: 2 )
E0VSD5_PEDHC
Pediculus humanus subsp. corporis
518
0
60541
TrEMBL
Mitochondrion (Reliability: 3 )
B7P9Q4_IXOSC
172
1
19898
TrEMBL
Secretory Pathway (Reliability: 1 )
B7P5J4_IXOSC
104
1
12180
TrEMBL
Secretory Pathway (Reliability: 1 )
B7P715_IXOSC
88
0
9934
TrEMBL
other Location (Reliability: 5 )
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expression in COS cells
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Zimniak, P.; Holsztynska, E.J.; Radominska, A.; Iscan, M.; Lester, R.; Waxman, D.J.
Distinct forms of cytochrome P-450 are responsible for 6beta-hydroxylation of bile acids and of neutral steroids
Biochem. J.
275
105-111
1991
Rattus norvegicus
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Chang, T.K.; Teixeira, J.; Gil, G.; Waxman, D.J.
The lithocholic acid 6beta-hydroxylase cytochrome P-450, CYP3A10, is an active catalyst of steroid-hormone 6beta-hydroxylation
Biochem. J.
291
429-433
1993
Mesocricetus auratus
brenda
Björkhem, I.; Danielsson, H.; Wikvall, K.
Hydroxylations of bile acids by reconstituted systems from rat liver microsomes
J. Biol. Chem.
249
6439-6445
1974
Rattus norvegicus
brenda
Teixeira, J.; Gil, G.
Cloning, expression, and regulation of lithocholic acid 6beta-hydroxylase
J. Biol. Chem.
266
21030-21036
1991
Mesocricetus auratus
brenda
Subramanian, A.; Teixeira, J.; Wang, J.; Gil, G.
A STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
Mol. Cell. Biol.
15
4672-4682
1995
Mesocricetus auratus
brenda
Subramanian, A.; Wang, J.; Gil, G.
STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase
Nucleic Acids Res.
26
2173-2178
1998
Mesocricetus auratus
brenda
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1.14.14.138 lithocholate 6beta-hydroxylase
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