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Results 1 - 3 of 3
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.138lithocholate + [reduced NADPH-hemoprotein reductase] + O2 a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.138lithocholate + [reduced NADPH-hemoprotein reductase] + O2 in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.138lithocholate + [reduced NADPH-hemoprotein reductase] + O2 the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
Results 1 - 3 of 3